DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, JB | ko |
dc.contributor.author | Yoon, JJ | ko |
dc.contributor.author | Lee, DS | ko |
dc.contributor.author | Park, Tae Gwan | ko |
dc.date.accessioned | 2009-11-24T03:00:03Z | - |
dc.date.available | 2009-11-24T03:00:03Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2004-12 | - |
dc.identifier.citation | JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, v.15, no.12, pp.1571 - 1583 | - |
dc.identifier.issn | 0920-5063 | - |
dc.identifier.uri | http://hdl.handle.net/10203/13190 | - |
dc.description.abstract | Thermo-sensitive and biodegradable hydrogels based on Pluronic tri-block copolymers were prepared by a photo-polymerization method. Two terminal hydroxyl groups in Pluronic F-127 were acrylated to form a Pluronic macromer. Photo-cross-linked Pluronic hydrogels prepared by UV radiation showed a gradually decreased swelling ratio with increasing temperature and exhibited a thermally-responsive change in the swelling ratio when the temperature was cycled between 10degreesC and 37degreesC. These hydrogels degraded slowly due to the cleavage of ester linkage in the acrylated Pluronic terminal end. When lysozyme, a model protein drug, was loaded in the hydrogels, bi-phasic protein release profiles were attained: a burst-free and rapid controlled release profile was initially observed for a one week period and a much slower sustained release was followed thereafter. The release rates could be controlled by varying the amount of Pluronic macromer for photo-polymerization. | - |
dc.description.sponsorship | the Korea Science and Engineering Foundation, Korea | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.subject | DRUG-DELIVERY SYSTEMS | - |
dc.subject | HUMAN GROWTH-HORMONE | - |
dc.subject | BLOCK-COPOLYMERS | - |
dc.subject | SENSITIVE HYDROGELS | - |
dc.subject | TEMPERATURE | - |
dc.subject | DEGRADATION | - |
dc.subject | MACROMOLECULES | - |
dc.subject | STABILITY | - |
dc.subject | BEHAVIOR | - |
dc.subject | INSULIN | - |
dc.title | Photo-crosslinkable, thermo-sensitive and biodegradable Pluronic hydrogels for sustained release of protein | - |
dc.type | Article | - |
dc.identifier.wosid | 000226533300008 | - |
dc.identifier.scopusid | 2-s2.0-11044224991 | - |
dc.type.rims | ART | - |
dc.citation.volume | 15 | - |
dc.citation.issue | 12 | - |
dc.citation.beginningpage | 1571 | - |
dc.citation.endingpage | 1583 | - |
dc.citation.publicationname | JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION | - |
dc.identifier.doi | 10.1163/1568562042459751 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Park, Tae Gwan | - |
dc.contributor.nonIdAuthor | Lee, JB | - |
dc.contributor.nonIdAuthor | Yoon, JJ | - |
dc.contributor.nonIdAuthor | Lee, DS | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | DRUG-DELIVERY SYSTEMS | - |
dc.subject.keywordPlus | HUMAN GROWTH-HORMONE | - |
dc.subject.keywordPlus | BLOCK-COPOLYMERS | - |
dc.subject.keywordPlus | SENSITIVE HYDROGELS | - |
dc.subject.keywordPlus | TEMPERATURE | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | MACROMOLECULES | - |
dc.subject.keywordPlus | STABILITY | - |
dc.subject.keywordPlus | BEHAVIOR | - |
dc.subject.keywordPlus | INSULIN | - |
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