DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Sun Hwa | ko |
dc.contributor.author | Lee, Soo Hyeon | ko |
dc.contributor.author | Tian, Huayu | ko |
dc.contributor.author | Chen, Xuesi | ko |
dc.contributor.author | Park, Tae Gwan | ko |
dc.date.accessioned | 2009-11-23T06:10:20Z | - |
dc.date.available | 2009-11-23T06:10:20Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2009-05 | - |
dc.identifier.citation | JOURNAL OF DRUG TARGETING, v.17, no.4, pp.311 - 317 | - |
dc.identifier.issn | 1061-186X | - |
dc.identifier.uri | http://hdl.handle.net/10203/13118 | - |
dc.description.abstract | A polymeric gene carrier was developed to deliver vascular endothelial growth factor (VEGF) small interfering RNA (siRNA) for prostate cancer cells in a target-specific manner. Prostate cancer-binding peptide (PCP) was conjugated with polyethylenimine (PEI) via a poly(ethylene glycol) (PEG) linker (PEI-PEG-PCP). The PEI-PEG-PCP conjugate could effectively condense siRNA to form stable polyelectrolyte complexes (polyplexes) with an average diameter of approximately 150 nm in an aqueous solution. VEGF siRNA/PEI-PEG-PCP polyplexes exhibited significantly higher VEGF inhibition efficiency than PCP-unmodified polycationic carriers (PEI-PEG or PEI) in human prostate carcinoma cells (PC-3 cells). The enhanced gene silencing activity of VEGF siRNA/PEI-PEG-PCP was maintained even under serum conditions, owing to the steric stabilization of the polyplexes with hydrophilic PEG grafts. Confocal microscopic studies revealed that the siRNA/PEI-PEG-PCP polyplexes were delivered into PC-3 cells in a PCP ligand-specific manner. | - |
dc.description.sponsorship | the grant (F104AA010002- 07A0101-00210) and A3 project from the Ministry of Education, Science and Technology, Republic of Korea. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | INFORMA HEALTHCARE | - |
dc.subject | POLYELECTROLYTE COMPLEX MICELLES | - |
dc.subject | MEDIATED DELIVERY | - |
dc.subject | RNA INTERFERENCE | - |
dc.subject | GENE DELIVERY | - |
dc.subject | PLASMID DNA | - |
dc.subject | GLYCOL) | - |
dc.subject | THERAPY | - |
dc.subject | GROWTH | - |
dc.subject | COPOLYMERS | - |
dc.subject | PEI | - |
dc.title | Prostate cancer cell-specific VEGF siRNA delivery system using cell targeting peptide conjugated polyplexes | - |
dc.type | Article | - |
dc.identifier.wosid | 000266593800007 | - |
dc.identifier.scopusid | 2-s2.0-70349536942 | - |
dc.type.rims | ART | - |
dc.citation.volume | 17 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 311 | - |
dc.citation.endingpage | 317 | - |
dc.citation.publicationname | JOURNAL OF DRUG TARGETING | - |
dc.identifier.doi | 10.1080/10611860902767232 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Park, Tae Gwan | - |
dc.contributor.nonIdAuthor | Kim, Sun Hwa | - |
dc.contributor.nonIdAuthor | Lee, Soo Hyeon | - |
dc.contributor.nonIdAuthor | Tian, Huayu | - |
dc.contributor.nonIdAuthor | Chen, Xuesi | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Prostate cancer-targeted siRNA delivery system | - |
dc.subject.keywordAuthor | VEGF | - |
dc.subject.keywordAuthor | siRNA | - |
dc.subject.keywordAuthor | prostate cancer-binding peptide (PCP) | - |
dc.subject.keywordPlus | POLYELECTROLYTE COMPLEX MICELLES | - |
dc.subject.keywordPlus | MEDIATED DELIVERY | - |
dc.subject.keywordPlus | RNA INTERFERENCE | - |
dc.subject.keywordPlus | GENE DELIVERY | - |
dc.subject.keywordPlus | PLASMID DNA | - |
dc.subject.keywordPlus | GLYCOL) | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | COPOLYMERS | - |
dc.subject.keywordPlus | PEI | - |
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