DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoo, HS | ko |
dc.contributor.author | Lee, EA | ko |
dc.contributor.author | Park, Tae-Gwan | ko |
dc.date.accessioned | 2009-11-23T05:06:00Z | - |
dc.date.available | 2009-11-23T05:06:00Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2002-06 | - |
dc.identifier.citation | JOURNAL OF CONTROLLED RELEASE, v.82, no.1, pp.17 - 27 | - |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.uri | http://hdl.handle.net/10203/13108 | - |
dc.description.abstract | Doxorubicin was chemically conjugated to the terminal end of a di-block copolymer composed of poly(L-lactic acid) (PLLA) and methoxy-poly(ethylene glycol) (mPEG) via two acid-cleavable linkages. A hydrazone bond and a cis-acotinyl bond were formed between doxorubicin and the terminal group of PLLA segment in the block copolymer. Doxorubicin-conjugated PLLA-mPEG di-block copolymers self-assembled to form micelles in aqueous solution. The doxorubicin-conjugated micelles were about 89.1 nm in diameter and their critical micelle concentration was 1.3 mug/ml. These values were comparable with those of unconjugated micelles. In an acidic condition, the conjugated doxorubicin in the hydrazone linkage was readily cleaved, releasing doxorubicin in an intact structure. Doxorubicin-conjugated PLLA-mPEG micelles were more potent in cell cytotoxicity than free doxorubicin, suggesting that they were more easily taken up within cells with concomitant rapid release of cleaved doxorubicin into the cytoplasm from acidic endosomes. (C) 2002 Elsevier Science B.V. All rights reserved. | - |
dc.description.sponsorship | the Center for Advanced Functional Polymers, KAIST, Korea. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Doxorubicin-conjugated biodegradable polymeric micelles having acid-cleavable linkages | - |
dc.type | Article | - |
dc.identifier.wosid | 000177478800002 | - |
dc.identifier.scopusid | 2-s2.0-0037130252 | - |
dc.type.rims | ART | - |
dc.citation.volume | 82 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 17 | - |
dc.citation.endingpage | 27 | - |
dc.citation.publicationname | JOURNAL OF CONTROLLED RELEASE | - |
dc.identifier.doi | 10.1016/S0168-3659(02)00088-3 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Park, Tae-Gwan | - |
dc.contributor.nonIdAuthor | Yoo, HS | - |
dc.contributor.nonIdAuthor | Lee, EA | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | doxorubicin | - |
dc.subject.keywordAuthor | biodegradable | - |
dc.subject.keywordAuthor | micelles | - |
dc.subject.keywordAuthor | PLLA-PEG di-block copolymer | - |
dc.subject.keywordAuthor | conjugation | - |
dc.subject.keywordPlus | FREE DRUG | - |
dc.subject.keywordPlus | ADRIAMYCIN | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | COPOLYMER | - |
dc.subject.keywordPlus | CARRIERS | - |
dc.subject.keywordPlus | RELEASE | - |
dc.subject.keywordPlus | FATE | - |
dc.subject.keywordPlus | PH | - |
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