DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bae, Ki-Hyun | ko |
dc.contributor.author | Choi, Seung-Ho | ko |
dc.contributor.author | Park, Sung-Young | ko |
dc.contributor.author | Lee, Yu-Han | ko |
dc.contributor.author | Park, Tae-Gwan | ko |
dc.date.accessioned | 2009-11-20T07:08:31Z | - |
dc.date.available | 2009-11-20T07:08:31Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2006-07 | - |
dc.identifier.citation | LANGMUIR, v.22, no.14, pp.6380 - 6384 | - |
dc.identifier.issn | 0743-7463 | - |
dc.identifier.uri | http://hdl.handle.net/10203/13020 | - |
dc.description.abstract | Gold nanoparticles were employed to prepare shell cross-linked Pluronic micelles that exhibit a reversibly thermosensitive swelling/shrinking behavior. Two terminal hydroxyl groups of Pluronic F127 were thiol-functionalized to form self-assembling Pluronic micelles in aqueous solution with exposed -SH groups in an outer shell layer. The thiol groups present in the outer shell were cross-linked by gold nanoparticles synthesized through NaBH4 reduction of gold precursor anions. The resultant shell cross-linked gold-Pluronic micelles exhibited a temperature-dependent volume transition: their hydrodynamic diameter was changed from 157.1 +/- 15.6 nm at 15 degrees C to 53.4 +/- 5.5 nm at 37 C as determined by dynamic light scattering. The critical micelle temperature measured by a pyrene solubilization technique suggested that the reversible swelling/shrinking behavior of the micelles was caused by hydrophobic interactions of cross-linked or grafted Pluronic copolymer chains in the micelle structure with increasing temperature. Transmission electron microscopy directly revealed that the shell cross-linked micelles were indeed produced by gold nanoparticles covalently clustered on the surface. These novel self-assembled organic/inorganic hybrid micelles would hold great potential for diagnostic and therapeutic applications. | - |
dc.description.sponsorship | National Research Laboratory program from the Ministry of Science and Technology, Republic of Korea. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | Amer Chemical Soc | - |
dc.subject | BLOCK-COPOLYMER SOLUTIONS | - |
dc.subject | POLYMER THERAPEUTICS | - |
dc.subject | LINKED MICELLES | - |
dc.subject | DRUG | - |
dc.subject | TEMPERATURE | - |
dc.subject | NANOSPHERES | - |
dc.subject | DELIVERY | - |
dc.subject | CORE | - |
dc.subject | POLYNUCLEOTIDES | - |
dc.subject | ASSOCIATION | - |
dc.title | Thermosensitive pluronic micelles stabilized by shell cross-linking with gold nanoparticles | - |
dc.type | Article | - |
dc.identifier.wosid | 000238558500059 | - |
dc.identifier.scopusid | 2-s2.0-33746562325 | - |
dc.type.rims | ART | - |
dc.citation.volume | 22 | - |
dc.citation.issue | 14 | - |
dc.citation.beginningpage | 6380 | - |
dc.citation.endingpage | 6384 | - |
dc.citation.publicationname | LANGMUIR | - |
dc.identifier.doi | 10.1021/la0606704 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Park, Tae-Gwan | - |
dc.contributor.nonIdAuthor | Choi, Seung-Ho | - |
dc.contributor.nonIdAuthor | Park, Sung-Young | - |
dc.contributor.nonIdAuthor | Lee, Yu-Han | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | BLOCK-COPOLYMER SOLUTIONS | - |
dc.subject.keywordPlus | POLYMER THERAPEUTICS | - |
dc.subject.keywordPlus | LINKED MICELLES | - |
dc.subject.keywordPlus | DRUG | - |
dc.subject.keywordPlus | TEMPERATURE | - |
dc.subject.keywordPlus | NANOSPHERES | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | CORE | - |
dc.subject.keywordPlus | POLYNUCLEOTIDES | - |
dc.subject.keywordPlus | ASSOCIATION | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.