Polyelectrolyte complex micelles composed of c-raf antisense oligodeoxynucleotide-poly(ethylene glycol) conjugate and poly(ethylenimine): Effect of systemic administration on tumor growth

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dc.contributor.authorJeong, JHko
dc.contributor.authorKim, SHko
dc.contributor.authorKim, SWko
dc.contributor.authorPark, Tae Gwanko
dc.date.accessioned2009-11-20T06:54:51Z-
dc.date.available2009-11-20T06:54:51Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2005-
dc.identifier.citationBIOCONJUGATE CHEMISTRY, v.16, no.4, pp.1034 - 1037-
dc.identifier.issn1043-1802-
dc.identifier.urihttp://hdl.handle.net/10203/13017-
dc.description.abstractAn antisense oligodeoxymicleotide (ODN) delivery system based on polyelectrolyte complex (PEC) micelles composed of an ODN-poly(ethylene glycol) (PEG) conjugate and polyethylenimine (PEI) was demonstrated. The PEC micelles having a core/shell structure were spontaneously formed in an aqueous solution by ionic interactions between ODN part in the conjugate and PEI. The ODN/PEI polyelectrolyte complex formed an inner core while PEG chains surrounded it as a shell. The morphology of the micelles was visualized as a separate sphere by atomic force microscopy (AFM). When the micelles containing a c-raf antisense ODN were intravenously administered into tumor-bearing nude mice, significant antitumor activities against human lung cancer were observed. The intravenously injected micelles also showed significantly higher accumulation level in the solid tumor region compared to that of naked ODN.-
dc.description.sponsorshipthe Ministry of Science and Technology, Republic of Korea.en
dc.languageEnglish-
dc.language.isoen_USen
dc.publisherAMER CHEMICAL SOC-
dc.subjectBLOCK-COPOLYMER MICELLES-
dc.subjectBIODEGRADABLE POLYMERIC MICELLES-
dc.subjectDELIVERY-SYSTEM-
dc.subjectDRUG-DELIVERY-
dc.subjectOLIGONUCLEOTIDES-
dc.subjectDNA-
dc.subjectL-ASPARTATE)-
dc.subjectADRIAMYCIN-
dc.subjectLIPOSOMES-
dc.subjectCARCINOMA-
dc.titlePolyelectrolyte complex micelles composed of c-raf antisense oligodeoxynucleotide-poly(ethylene glycol) conjugate and poly(ethylenimine): Effect of systemic administration on tumor growth-
dc.typeArticle-
dc.identifier.wosid000230712900034-
dc.identifier.scopusid2-s2.0-22644432986-
dc.type.rimsART-
dc.citation.volume16-
dc.citation.issue4-
dc.citation.beginningpage1034-
dc.citation.endingpage1037-
dc.citation.publicationnameBIOCONJUGATE CHEMISTRY-
dc.identifier.doi10.1021/bc0497315-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorPark, Tae Gwan-
dc.contributor.nonIdAuthorJeong, JH-
dc.contributor.nonIdAuthorKim, SH-
dc.contributor.nonIdAuthorKim, SW-
dc.type.journalArticleArticle-
dc.subject.keywordPlusBLOCK-COPOLYMER MICELLES-
dc.subject.keywordPlusBIODEGRADABLE POLYMERIC MICELLES-
dc.subject.keywordPlusDELIVERY-SYSTEM-
dc.subject.keywordPlusDRUG-DELIVERY-
dc.subject.keywordPlusOLIGONUCLEOTIDES-
dc.subject.keywordPlusDNA-
dc.subject.keywordPlusL-ASPARTATE)-
dc.subject.keywordPlusADRIAMYCIN-
dc.subject.keywordPlusLIPOSOMES-
dc.subject.keywordPlusCARCINOMA-
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