siRNA Conjugate Delivery Systems

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Small interfering RNA (siRNA) has been chemically conjugated to a variety of bioactive molecules, lipids, polymers, peptides, and inorganic nanostructured materials to enhance their pharmacokinetic behavior, cellular uptake, target specificity, and safety. To efficiently deliver siRNAs to the target cells and tissues, many different siRNA bioconjugates were synthesized and characterized, and their gene silencing efficiencies were tested in vitro and in vivo. In this review, recent developments of siRNA bioconjugates are summarized.
Publisher
Amer Chemical Soc
Issue Date
2009-11
Language
English
Article Type
Review
Keywords

POLYELECTROLYTE COMPLEX MICELLES; CELL-PENETRATING PEPTIDES; SMALL INTERFERING RNA; POLY(ETHYLENE GLYCOL)-SIRNA CONJUGATE; TAT-DEPENDENT TRANSACTIVATION; CATIONIC FUSOGENIC PEPTIDE; CULTURED-MAMMALIAN-CELLS; INNATE IMMUNE-RESPONSE; TARGETING IN-VIVO; INTRACELLULAR DELIVERY

Citation

BIOCONJUGATE CHEMISTRY, v.20, no.1, pp.5 - 14

ISSN
1043-1802
URI
http://hdl.handle.net/10203/12990
Appears in Collection
BS-Journal Papers(저널논문)
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