DC Field | Value | Language |
---|---|---|
dc.contributor.author | Dayananda, Kasala | ko |
dc.contributor.author | He, Chaoliang | ko |
dc.contributor.author | Park, Dong Kuk | ko |
dc.contributor.author | Park, Tae Gwan | ko |
dc.contributor.author | Lee, Doo Sung | ko |
dc.date.accessioned | 2009-11-11T05:41:57Z | - |
dc.date.available | 2009-11-11T05:41:57Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2008-10 | - |
dc.identifier.citation | POLYMER, v.49, no.23, pp.4968 - 4973 | - |
dc.identifier.issn | 0032-3861 | - |
dc.identifier.uri | http://hdl.handle.net/10203/12417 | - |
dc.description.abstract | A series of novel pH- and temperature-responsive multiblock copolymers (poly(PEG/HEP urethane)) consisting of poly(ethylene glycol) (PEG) and poly(amino urethane) (PAU) were synthesized, and their physicochemical properties were studied. The amphiphilic block copolymers were synthesized from PEG, 1,4-bis(hydroxyethyl) piperazine (HEP) and 1,6-diisocyanato hexamethylene (HDI) in the presence of dibutyltin dilaurate as a catalyst. The resulting polymers were examined by FT-IR, H-1 and C-13 NMR spectroscopies and gel permeation chromatography (GPC). The solution properties of the copolymers were studied by turbidity measurement and fluorescence spectroscopy. The copolymers showed a pH-dependent soluble-insoluble transition in diluted aqueous solutions. The concentrated polymer solutions exhibited a thermo-induced sol-gel-sol phase transition at pH 6.8-7.4. The gel window covers the physiological conditions. After a subcutaneous injection of the multiblock copolymer solution into mice, a transparent and soft gel was formed immediately. The in vitro release of a model anticancer drug, chlorambucil, persisted over 2 weeks under physiological conditions. (C) 2008 Elsevier Ltd. All rights reserved. | - |
dc.description.sponsorship | Korea Research Foundation Grant | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | Elsevier Sci Ltd | - |
dc.subject | BLOCK-COPOLYMERS | - |
dc.subject | AQUEOUS-SOLUTIONS | - |
dc.subject | HYALURONIC-ACID | - |
dc.subject | GELS | - |
dc.subject | POLYURETHANES | - |
dc.subject | DELIVERY | - |
dc.subject | BEHAVIOR | - |
dc.title | pH- and temperature-sensitive multiblock copolymer hydrogels composed of poly(ethylene glycol) and poly(amino urethane) | - |
dc.type | Article | - |
dc.identifier.wosid | 000260599400008 | - |
dc.identifier.scopusid | 2-s2.0-54249110943 | - |
dc.type.rims | ART | - |
dc.citation.volume | 49 | - |
dc.citation.issue | 23 | - |
dc.citation.beginningpage | 4968 | - |
dc.citation.endingpage | 4973 | - |
dc.citation.publicationname | POLYMER | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Park, Tae Gwan | - |
dc.contributor.nonIdAuthor | Dayananda, Kasala | - |
dc.contributor.nonIdAuthor | He, Chaoliang | - |
dc.contributor.nonIdAuthor | Park, Dong Kuk | - |
dc.contributor.nonIdAuthor | Lee, Doo Sung | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Stimuli-sensitive polymers | - |
dc.subject.keywordAuthor | Injectable hydrogel | - |
dc.subject.keywordAuthor | Poly(amino urethane) | - |
dc.subject.keywordPlus | BLOCK-COPOLYMERS | - |
dc.subject.keywordPlus | AQUEOUS-SOLUTIONS | - |
dc.subject.keywordPlus | HYALURONIC-ACID | - |
dc.subject.keywordPlus | GELS | - |
dc.subject.keywordPlus | POLYURETHANES | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | BEHAVIOR | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.