DSpace at KOASAS
College of Life Science and Bioengineering(생명과학기술대학)Dept. of Biological Sciences(생명과학과)BS-Journal Papers(저널논문)

Dissolution of biomacromolecules in organic solvents by nano-complexing with poly(ethylene glycol)

Cited 15 time in webofscience Cited 18 time in scopus
  • Hit : 478
  • Download : 110
Export
DC FieldValueLanguage
dc.contributor.authorMok, Hyejungko
dc.contributor.authorKim, Ho Jeongko
dc.contributor.authorPark, Tae Gwanko
dc.date.accessioned2009-11-11T01:42:45Z-
dc.date.available2009-11-11T01:42:45Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2008-05-
dc.identifier.citationINTERNATIONAL JOURNAL OF PHARMACEUTICS, v.356, no.1-2, pp.306 - 313-
dc.identifier.issn0378-5173-
dc.identifier.urihttp://hdl.handle.net/10203/12391-
dc.description.abstractVarious biomacromolecules (BMs) such as proteins, DNA, and carbohydrates are extremely difficult to be dissolved in a single organic solvent phase for sustained release or targeted delivery formulation. In this study, three different BMs could be solubilized in selected organic solvents by forming poly(ethylene glycol) (PEG)-assisted nano-complexes while maintaining their structural integrity. Dynamic light scattering (DLS) and atomic force microscopy (AFM) analysis revealed that proteins, DNA, and carbohydrate polymers could be nano-complexed with PEG in various organic solvents. The diameter of nano-complexes decreased roughly from similar to 600 nm to similar to 100 nm with increasing weight ratio of PEG/BM. The present solubilization technique could be potentially applied for sustained release formulations of various therapeutic biological drugs. (c) 2008 Elsevier B.V. All rights reserved.-
dc.description.sponsorshipNational Research Laboratory project from the Ministry of Science and Technology, Republic of Korea.en
dc.languageEnglish-
dc.language.isoen_USen
dc.publisherELSEVIER SCIENCE BV-
dc.subjectPHASE-SEPARATION-
dc.subjectPOLYETHYLENE-GLYCOLS-
dc.subjectTHERMAL-STABILITY-
dc.subjectPROTEINS-
dc.subjectLYOPHILIZATION-
dc.subjectDNA-
dc.subjectMICROSPHERES-
dc.subjectMECHANISM-
dc.subjectHYDRATION-
dc.subjectSYSTEMS-
dc.titleDissolution of biomacromolecules in organic solvents by nano-complexing with poly(ethylene glycol)-
dc.typeArticle-
dc.identifier.wosid000256129900039-
dc.identifier.scopusid2-s2.0-42649136546-
dc.type.rimsART-
dc.citation.volume356-
dc.citation.issue1-2-
dc.citation.beginningpage306-
dc.citation.endingpage313-
dc.citation.publicationnameINTERNATIONAL JOURNAL OF PHARMACEUTICS-
dc.identifier.doi10.1016/j.ijpharm.2008.01.033-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorPark, Tae Gwan-
dc.contributor.nonIdAuthorMok, Hyejung-
dc.contributor.nonIdAuthorKim, Ho Jeong-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorbiomacromolecules-
dc.subject.keywordAuthorbovine serum albumin-
dc.subject.keywordAuthorDNA-
dc.subject.keywordAuthorhyaluronic acid-
dc.subject.keywordAuthorpoly(ethylene glycol)-
dc.subject.keywordAuthorsolubilization in organic solvents-
dc.subject.keywordPlusPHASE-SEPARATION-
dc.subject.keywordPlusPOLYETHYLENE-GLYCOLS-
dc.subject.keywordPlusTHERMAL-STABILITY-
dc.subject.keywordPlusPROTEINS-
dc.subject.keywordPlusLYOPHILIZATION-
dc.subject.keywordPlusDNA-
dc.subject.keywordPlusMICROSPHERES-
dc.subject.keywordPlusMECHANISM-
dc.subject.keywordPlusHYDRATION-
dc.subject.keywordPlusSYSTEMS-
Appears in Collection
BS-Journal Papers(저널논문)
Files in This Item
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 15 items in WoS Click to see citing articles in records_button

Display Simple Item Record

qr_code

  • mendeley

    citeulike

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.


rss_1.0 rss_2.0 atom_1.0