A novel fabrication method of macroporous biodegradable polymer scaffolds using gas foaming salt as a porogen additive

Cited 449 time in webofscience Cited 512 time in scopus
  • Hit : 774
  • Download : 96
Highly open porous biodegradable poly(L-lactic acid) [PLLA] scaffolds for tissue regeneration were fabricated by using ammonium bicarbonate as an efficient gas foaming agent as well as a particulate porogen salt. A binary mixture of PLLA-solvent gel containing dispersed ammonium bicarbonate salt particles, which became a paste state, was cast in a mold and subsequently immersed in a hot water solution to permit the evolution of ammonia and carbon dioxide within the solidifying polymer matrix. This resulted in the expansion of pores within the polymer matrix to a great extent, leading to well interconnected macroporous scaffolds having mean pore diameters of around 300-400 mu m, ideal for high-density cell seeding. Rat hepatocytes seeded into the scaffolds exhibited about 95% seeding efficiency and up to 40% viability at 1 day after the seeding. The novelty of this new method is that the PLLA paste containing ammonium bicarbonate salt particles can be easily handled and molded into any shape, allowing for fabricating a wide range of temporal tissue scaffolds requiring a specific shape and geometry. (C) 2000 John Wiley & Sons, Inc.
Publisher
Wiley-Blackwell
Issue Date
2000
Language
English
Article Type
Article
Keywords

POLY(L-LACTIC ACID) FOAMS; TISSUE; TRANSPLANTATION; HEPATOCYTES; MATRICES; INVITRO; CULTURE

Citation

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, v.53, no.1, pp.1 - 7

ISSN
1549-3296
DOI
10.1002/(SICI)1097-4636(2000)53:1<1::AID-JBM1>3.0.CO;2-R
URI
http://hdl.handle.net/10203/11835
Appears in Collection
MS-Journal Papers(저널논문)BS-Journal Papers(저널논문)
Files in This Item
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 449 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0