Biodegradable polymeric microcellular foams by modified thermally induced phase separation method

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Thermally induced phase separation (TIPS) for the fabrication of porous foams based on various biodegradable polymers of poly(L-lactic acid) and its copolymers with D-lactic acid and/or glycolic acid is presented. Diverse foam morphologies were obtained by systematically changing several parameters involved in the TIPS process, such as polymer type and concentration, coarsening conditions, solvent/nonsolvent composition, and the presence of an additive. The produced foams had microcellular structures with average pore diameters ranging from 1 to 30 mu m depending on the process parameters, which were characterized by scanning electron microscopy (SEM) and mercury intrusion porosimetry. Additionally, Pluronic F127 was used as an additive porogen to control the pore geometry and size. (C) 1999 Elsevier Science Ltd. All rights reserved.
Publisher
ELSEVIER SCI LTD
Issue Date
1999-10
Language
English
Article Type
Article
Keywords

MICROPOROUS MEMBRANE FORMATION; POLY(L-LACTIC ACID) FOAMS; SPINODAL DECOMPOSITION; TRANSPLANTATION

Citation

BIOMATERIALS, v.20, no.19, pp.1783 - 1790

ISSN
0142-9612
DOI
10.1016/S0142-9612(99)00073-3
URI
http://hdl.handle.net/10203/11832
Appears in Collection
MS-Journal Papers(저널논문)BS-Journal Papers(저널논문)
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