CONTROLLED-RELEASE OF PROTEINS FROM POLY(L-LACTIC ACID) COATED POLYISOBUTYLCYANOACRYLATE MICROCAPSULES

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dc.contributor.authorTAE GWAN PARKko
dc.date.accessioned2009-09-07T05:30:30Z-
dc.date.available2009-09-07T05:30:30Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued1994-
dc.identifier.citationJOURNAL OF APPLIED POLYMER SCIENCE, v.52, no.12, pp.1797 - 1807-
dc.identifier.issn0021-8995-
dc.identifier.urihttp://hdl.handle.net/10203/11041-
dc.description.abstractPoly (L-lactic acid) -coated polyisobutylcyanoacrylate microcapsules containing protein molecules were prepared by a single-step procedure based on either a double-emulsion-solvent evaporation method or a spray-drying method. First, an aqueous protein solution was emulsified in an organic phase of methylene chloride containing a wall-forming monomer (isobutylcyanoacrylate), various kinds of poly(L-lactic acid), and a surfactant. An immediate polymerization process of isobutylcyanoacrylate takes place at the W/O interface upon contact with hydroxide ion in the aqueous phase, leading to the formation of a polyisobutylcyanoacrylate wall around the aqueous droplets. This W/O emulsion was reemulsified in an aqueous solution to promote the solvent removal and, consequently, the precipitation of poly(L-lactic acid) onto polyisobutylcyanoacrylate microcapsules or was spray-dried to directly deposit the poly (L-lactic acid) on the wall. Three proteins, bovine serum albumin, horseradish peroxidase, and tetanus toxoid, were encapsulated in these poly (L-lactic acid) -coated polyisobutylcyanoacrylate microcapsules, and then their release profiles were examined in vitro as a function of molecular weight of poly(L-lactic acid) and its copolymers with glycolic acid. These formulations exhibited a low ''burst'' effect at initial incubation stages and released the proteins for extended periods of time. Subcutaneous injections of the tetanus toxoid-loaded microparticles into rats showed that the time course of immunization (antibody titer) can be controlled by the type of polymer matrices used. (C) 1994 John Wiley & Sons, Inc.-
dc.languageEnglish-
dc.language.isoen_USen
dc.publisherJOHN WILEY & SONS INC-
dc.subjectMICROSPHERES-
dc.subjectNANOPARTICLES-
dc.subjectDEGRADATION-
dc.subjectDELIVERY-
dc.subjectMATRICES-
dc.subjectBLENDS-
dc.titleCONTROLLED-RELEASE OF PROTEINS FROM POLY(L-LACTIC ACID) COATED POLYISOBUTYLCYANOACRYLATE MICROCAPSULES-
dc.typeArticle-
dc.identifier.wosidA1994NM29600014-
dc.identifier.scopusid2-s2.0-0028452799-
dc.type.rimsART-
dc.citation.volume52-
dc.citation.issue12-
dc.citation.beginningpage1797-
dc.citation.endingpage1807-
dc.citation.publicationnameJOURNAL OF APPLIED POLYMER SCIENCE-
dc.identifier.doi10.1002/app.1994.070521214-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorTAE GWAN PARK-
dc.type.journalArticleArticle-
dc.subject.keywordPlusMICROSPHERES-
dc.subject.keywordPlusNANOPARTICLES-
dc.subject.keywordPlusDEGRADATION-
dc.subject.keywordPlusDELIVERY-
dc.subject.keywordPlusMATRICES-
dc.subject.keywordPlusBLENDS-
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