DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Seung Rim | - |
dc.contributor.author | Kim, Seung Beon | - |
dc.contributor.author | Joe, Cheol O. | - |
dc.contributor.author | Kim, Jong-Duk | - |
dc.date.accessioned | 2009-08-24T01:19:20Z | - |
dc.date.available | 2009-08-24T01:19:20Z | - |
dc.date.issued | 2005-07-25 | - |
dc.identifier.citation | Biotechnology Letters, Vol.27, No.14, pp.977-982 | en |
dc.identifier.issn | 0141-5492 | - |
dc.identifier.uri | http://hdl.handle.net/10203/10685 | - |
dc.description.abstract | Nω-2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl (Nω-Pbf)-protected oligoarginine was directly conjugated to poly(amino acid) derivatives modified with a long alkyl chain. The final concentration of conjugated peptides was easily controlled by the feed ratio of oligoarginine to polymer backbone and a final soluble polymeric system was obtained by the deprotection of Nω-Pbf groups. The polymeric conjugates formed stable self-aggregates of size range of 8–40 nm in aqueous solution and effectively internalized into HeLa cells by adsorptive endocytosis. | en |
dc.description.sponsorship | Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, 305-701 Guseong-dong, Yuseong-gu, Daejeon, Republic of Korea | en |
dc.language.iso | en_US | en |
dc.publisher | Springer Verlag (Germany) | en |
dc.subject | intracellular delivery | en |
dc.subject | oligoarginine | en |
dc.subject | self-aggregates | en |
dc.subject | poly(amino acid)s | en |
dc.title | Self-aggregates of oligoarginine-conjugated poly(amino acid) derivatives as a carrier for intracellular drug delivery | en |
dc.type | Article | en |
dc.identifier.doi | 10.1007/s10529-005-7838-4 | - |
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