Self-aggregates of oligoarginine-conjugated poly(amino acid) derivatives as a carrier for intracellular drug delivery

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Nω-2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl (Nω-Pbf)-protected oligoarginine was directly conjugated to poly(amino acid) derivatives modified with a long alkyl chain. The final concentration of conjugated peptides was easily controlled by the feed ratio of oligoarginine to polymer backbone and a final soluble polymeric system was obtained by the deprotection of Nω-Pbf groups. The polymeric conjugates formed stable self-aggregates of size range of 8–40 nm in aqueous solution and effectively internalized into HeLa cells by adsorptive endocytosis.
Publisher
Springer Verlag (Germany)
Issue Date
2005-07-25
Keywords

intracellular delivery; oligoarginine; self-aggregates; poly(amino acid)s

Citation

Biotechnology Letters, Vol.27, No.14, pp.977-982

ISSN
0141-5492
DOI
10.1007/s10529-005-7838-4
URI
http://hdl.handle.net/10203/10685
Appears in Collection
BS-Conference Papers(학술회의논문)

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