DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, JH | ko |
dc.contributor.author | Park, Tae-Gwan | ko |
dc.date.accessioned | 2009-08-18T08:51:48Z | - |
dc.date.available | 2009-08-18T08:51:48Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2002-07 | - |
dc.identifier.citation | JOURNAL OF CONTROLLED RELEASE, v.82, no.0, pp.159 - 166 | - |
dc.identifier.issn | 0168-3659 | - |
dc.identifier.uri | http://hdl.handle.net/10203/10598 | - |
dc.description.abstract | Poly(lactic-co-glycolic acid) (PLGA)-grafted poly(L-lysine) (PLL) (PLL-g-PLGA) was synthesized to demonstrate its micelle-forming property in an aqueous solution. The micelles were used as a gene delivery carrier. The hydrodynamic diameter of PLL-g-PLGA micelles in an aqueous solution was ca. 149 nm with a narrow size distribution. Critical micelle concentration (cmc) was 9.6 mg/l. The PLL-g-PLGA micelles could be used to produce compact nanoparticulate complexes with plasmid DNA, which could efficiently protect the complexed DNA from enzymatic degradation by DNase I. The micelle/DNA complexes had highly compacted structure sized between 200-300 nm with a positive surface charge value. The PLL-g-PLGA micelles exhibited much higher transfection efficiency with lower cytotoxicity than PLL. Here, we demonstrated that biodegradable and cationic PLL-g-PLGA micelles could be used as an effective DNA condensation carrier for gene delivery system. (C) 2002 Elsevier Science B.V. All rights reserved. | - |
dc.description.sponsorship | the grants from the Ministry of Health and Welfare (HMP-99-B-02- 0002) and from the Center for Advanced Functional Polymers (KAIST), Republic of Korea. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Poly(L-lysine)-g-poly(D,L-lactic-co-glycolic acid) micelles for low cytotoxic biodegradable gene delivery carriers | - |
dc.type | Article | - |
dc.identifier.wosid | 000177478800015 | - |
dc.identifier.scopusid | 2-s2.0-0037130190 | - |
dc.type.rims | ART | - |
dc.citation.volume | 82 | - |
dc.citation.issue | 0 | - |
dc.citation.beginningpage | 159 | - |
dc.citation.endingpage | 166 | - |
dc.citation.publicationname | JOURNAL OF CONTROLLED RELEASE | - |
dc.identifier.doi | 10.1016/S0168-3659(02)00131-1 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Park, Tae-Gwan | - |
dc.contributor.nonIdAuthor | Jeong, JH | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | non-viral vector | - |
dc.subject.keywordAuthor | poly(L-lysine) | - |
dc.subject.keywordAuthor | PLGA | - |
dc.subject.keywordAuthor | biodegradable | - |
dc.subject.keywordAuthor | transfection | - |
dc.subject.keywordPlus | POLY-L-LYSINE | - |
dc.subject.keywordPlus | POLY(METHYL METHACRYLATE)-GRAFT-POLYSTYRENE | - |
dc.subject.keywordPlus | TRANSFECTION EFFICIENCY | - |
dc.subject.keywordPlus | PLASMID DNA | - |
dc.subject.keywordPlus | OLIGONUCLEOTIDES | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | POLYLYSINE | - |
dc.subject.keywordPlus | VECTOR | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | POLYETHYLENIMINE | - |
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