DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, S. -H. | ko |
dc.contributor.author | Park, H. -W. | ko |
dc.contributor.author | Kim, M. -J. | ko |
dc.contributor.author | Noh, M. -H. | ko |
dc.contributor.author | Yoon, H. -S. | ko |
dc.contributor.author | Choi, B. -M. | ko |
dc.contributor.author | Lee, E. -K. | ko |
dc.contributor.author | Noh, G. -J. | ko |
dc.date.accessioned | 2013-03-13T06:20:37Z | - |
dc.date.available | 2013-03-13T06:20:37Z | - |
dc.date.created | 2012-08-21 | - |
dc.date.created | 2012-08-21 | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, v.35, no.4, pp.329 - 341 | - |
dc.identifier.issn | 0140-7783 | - |
dc.identifier.uri | http://hdl.handle.net/10203/104649 | - |
dc.description.abstract | Lee, S.-H., Park, H.-W., Kim, M.-J., Noh, M.-H., Yoon, H.-S., Choi, B.-M., Lee, E.-K., Noh, G.-J. External validation of pharmacokinetic and pharmacodynamic models of microemulsion and long-chain triglyceride emulsion propofol in beagle dogs. J. vet. Pharmacol. Therap. 35, 329-341. This study aimed at assessing the predictive performance of a target-controlled infusion (TCI) system, which incorporates canine PKPD models for microemulsion and long-chain triglyceride emulsion (LCT) propofol and at investigating time independency of propofol effect on the observed electroencephalographic approximate entropy (ApEn) in TCI. Using a crossover design with a 7-day washout period, 28 healthy beagle dogs were randomized to receive TCI of both formulations in a stepwise or constant manner. Plasma propofol concentrations and ApEn were measured at preset intervals. Pooled biases, inaccuracies, divergences, and wobbles in pharmacokinetic and pharmacodynamic predictions were 2.1% (95% CI: -0.8 to 4.9), 18.1% (15.620.5), 1.9%/h, 7.3% (5.49.3), and -0.5% (-2.6 to 1.6), 8.7% (7.310.1), 2.5%/h, 6.0% (4.17.2) for microemulsion propofol, and -9.3% (-11.6 to -6.9), 20.1% (18.222.0), 5.1%/h, 7.6% (6.19.1) and 5.6% (4.17.1), 8.0% (6.99.3), 4.7%/h, 4.1% (3.15.1) for LCT propofol. Observed ApEn values over time were statistically not different across all time points in a TCI with constant manner. Canine PKPD model of microemulsion propofol showed good predictive performances. Propofol effect (ApEn) was time independent as long as time is allowed for equilibration. | - |
dc.language | English | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.subject | COMPUTER-CONTROLLED INFUSION | - |
dc.subject | TARGET-CONTROLLED INFUSION | - |
dc.subject | EFFECT-SITE CONCENTRATION | - |
dc.subject | PREDICTIVE PERFORMANCE | - |
dc.subject | VOLUNTEERS | - |
dc.subject | ANESTHESIA | - |
dc.subject | SURGERY | - |
dc.subject | TIME | - |
dc.title | External validation of pharmacokinetic and pharmacodynamic models of microemulsion and long-chain triglyceride emulsion propofol in beagle dogs | - |
dc.type | Article | - |
dc.identifier.wosid | 000306006100003 | - |
dc.identifier.scopusid | 2-s2.0-84863553396 | - |
dc.type.rims | ART | - |
dc.citation.volume | 35 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 329 | - |
dc.citation.endingpage | 341 | - |
dc.citation.publicationname | JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS | - |
dc.identifier.doi | 10.1111/j.1365-2885.2011.01321.x | - |
dc.contributor.nonIdAuthor | Lee, S. -H. | - |
dc.contributor.nonIdAuthor | Kim, M. -J. | - |
dc.contributor.nonIdAuthor | Noh, M. -H. | - |
dc.contributor.nonIdAuthor | Yoon, H. -S. | - |
dc.contributor.nonIdAuthor | Choi, B. -M. | - |
dc.contributor.nonIdAuthor | Lee, E. -K. | - |
dc.contributor.nonIdAuthor | Noh, G. -J. | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | COMPUTER-CONTROLLED INFUSION | - |
dc.subject.keywordPlus | TARGET-CONTROLLED INFUSION | - |
dc.subject.keywordPlus | EFFECT-SITE CONCENTRATION | - |
dc.subject.keywordPlus | PREDICTIVE PERFORMANCE | - |
dc.subject.keywordPlus | VOLUNTEERS | - |
dc.subject.keywordPlus | ANESTHESIA | - |
dc.subject.keywordPlus | SURGERY | - |
dc.subject.keywordPlus | TIME | - |
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