Recent advances in production of recombinant spider silk proteins

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Spider silk has been drawing much attention as a great biomaterial having many applications in biotechnology and biomedicine owing to its several desired material characteristics such as outstanding strength, toughness, and elasticity as well as biodegradability and biocompatibility. With various applications foreseeable in industry, there has been much effort to produce recombinant spider silk protein in large amounts. However, owing to the difficulties in its production using spiders, alternative host systems and engineering methods have been investigated to develop suitable production systems that can efficiently produce spider silk protein. Here, we review recent advances in production of spider silk proteins in various heterologous host systems with focus given on the development of metabolic and cellular engineering strategies.
Publisher
CURRENT BIOLOGY LTD
Issue Date
2012-12
Language
English
Article Type
Review
Citation

CURRENT OPINION IN BIOTECHNOLOGY, v.23, no.6, pp.957 - 964

ISSN
0958-1669
DOI
10.1016/j.copbio.2012.03.013
URI
http://hdl.handle.net/10203/104503
Appears in Collection
CBE-Journal Papers(저널논문)
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