CRIF1 Is Essential for the Synthesis and Insertion of Oxidative Phosphorylation Polypeptides in the Mammalian Mitochondrial Membrane

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dc.contributor.authorKim, Soung Jungko
dc.contributor.authorKwon, Min-chulko
dc.contributor.authorRyu, Min Jeongko
dc.contributor.authorChung, Hyo Kyunko
dc.contributor.authorTadi, Surendarko
dc.contributor.authorKim, Yong Kyungko
dc.contributor.authorKim, Jin Manko
dc.contributor.authorLee, Sang Heeko
dc.contributor.authorPark, Ji Hoonko
dc.contributor.authorKweon, Gi Ryangko
dc.contributor.authorRyu, Seung-Wookko
dc.contributor.authorJo, Young Sukko
dc.contributor.authorLee, Chul-Hoko
dc.contributor.authorHatakeyama, Hideyukiko
dc.contributor.authorGoto, Yu-ichiko
dc.contributor.authorYim, Yong-Hyeonko
dc.contributor.authorChung, Jongkyeongko
dc.contributor.authorKong, Young-Yunko
dc.contributor.authorShong, Minhoko
dc.date.accessioned2013-03-13T04:16:28Z-
dc.date.available2013-03-13T04:16:28Z-
dc.date.created2013-01-07-
dc.date.created2013-01-07-
dc.date.created2013-01-07-
dc.date.created2013-01-07-
dc.date.issued2012-08-
dc.identifier.citationCELL METABOLISM, v.16, no.2, pp.274 - 283-
dc.identifier.issn1550-4131-
dc.identifier.urihttp://hdl.handle.net/10203/104443-
dc.description.abstractAlthough substantial progress has been made in understanding the mechanisms underlying the expression of mtDNA-encoded polypeptides, the regulatory factors involved in mitoribosome-mediated synthesis and simultaneous insertion of mitochondrial oxidative phosphorylation (OXPHOS) polypeptides into the inner membrane of mitochondria are still unclear. In the present study, disruption of the mouse Crif1 gene, which encodes a mitochondrial protein, resulted in a profound deficiency in OXPHOS caused by the disappearance of OXPHOS subunits and complexes in vivo. CRIF1 was associated with large mitoribosomal subunits that were located close to the polypeptide exit tunnel, and the elimination of CRIF1 led to both aberrant synthesis and defective insertion of mtDNA-encoded nascent OXPHOS polypeptides into the inner membrane. CRIF1 interacted with nascent OXPHOS polypeptides and molecular chaperones, e.g., Tid1. Taken together, these results suggest that CRIF1 plays a critical role in the integration of OXPHOS polypeptides into the mitochondrial membrane in mammals.-
dc.languageEnglish-
dc.publisherCELL PRESS-
dc.titleCRIF1 Is Essential for the Synthesis and Insertion of Oxidative Phosphorylation Polypeptides in the Mammalian Mitochondrial Membrane-
dc.typeArticle-
dc.identifier.wosid000307615300016-
dc.identifier.scopusid2-s2.0-84864699265-
dc.type.rimsART-
dc.citation.volume16-
dc.citation.issue2-
dc.citation.beginningpage274-
dc.citation.endingpage283-
dc.citation.publicationnameCELL METABOLISM-
dc.identifier.doi10.1016/j.cmet.2012.06.012-
dc.contributor.localauthorShong, Minho-
dc.contributor.nonIdAuthorKim, Soung Jung-
dc.contributor.nonIdAuthorKwon, Min-chul-
dc.contributor.nonIdAuthorRyu, Min Jeong-
dc.contributor.nonIdAuthorChung, Hyo Kyun-
dc.contributor.nonIdAuthorTadi, Surendar-
dc.contributor.nonIdAuthorKim, Yong Kyung-
dc.contributor.nonIdAuthorKim, Jin Man-
dc.contributor.nonIdAuthorPark, Ji Hoon-
dc.contributor.nonIdAuthorKweon, Gi Ryang-
dc.contributor.nonIdAuthorJo, Young Suk-
dc.contributor.nonIdAuthorLee, Chul-Ho-
dc.contributor.nonIdAuthorHatakeyama, Hideyuki-
dc.contributor.nonIdAuthorGoto, Yu-ichi-
dc.contributor.nonIdAuthorYim, Yong-Hyeon-
dc.contributor.nonIdAuthorChung, Jongkyeong-
dc.contributor.nonIdAuthorKong, Young-Yun-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordPlusRIBOSOMAL-PROTEINS-
dc.subject.keywordPlusTRANSLATION-
dc.subject.keywordPlusSUBUNIT-
dc.subject.keywordPlusRNA-
dc.subject.keywordPlusCOMPONENTS-
dc.subject.keywordPlusDISEASE-
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