DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Ji-Hye | ko |
dc.contributor.author | Choi, Dae-Kyoung | ko |
dc.contributor.author | Sohn, Kyung-Cheol | ko |
dc.contributor.author | Kwak, Sang-Su | ko |
dc.contributor.author | Suk, Jin-Kyu | ko |
dc.contributor.author | Lim, Jong-Soon | ko |
dc.contributor.author | Shin, In-Cheol | ko |
dc.contributor.author | Kim, Sung-Woo | ko |
dc.contributor.author | Lee, Jeung-Hoon | ko |
dc.contributor.author | Joe, Cheol-O | ko |
dc.date.accessioned | 2013-03-13T02:19:00Z | - |
dc.date.available | 2013-03-13T02:19:00Z | - |
dc.date.created | 2012-09-28 | - |
dc.date.created | 2012-09-28 | - |
dc.date.issued | 2012-07 | - |
dc.identifier.citation | JOURNAL OF BIOLOGICAL CHEMISTRY, v.287, no.31, pp.25954 - 25963 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | http://hdl.handle.net/10203/104229 | - |
dc.description.abstract | The biochemical mechanism by which the human tumorous imaginal disc1(S) (hTid-1(S)) interferes with actin cytoskeleton organization in keratinocytes of human skin epidermis was investigated. We found that hTid-1, specifically hTid-1(S), interacts with MK5, a p38-regulated/activated protein kinase, and inhibits the protein kinase activity of MK5 that phosphorylates heat shock protein HSP27 in cultured HeLa cells. Thus, hTid-1(S) expression inhibits the phosphorylation of HSP27 known to play important roles in F-actin polymerization and actin cytoskeleton organization. The interplay between MK5/HSP27 signaling and hTid-1(S) expression was supported by the inhibition of HSP27 phosphorylation and MK5 activity in HeLa cells in response to hypoxia during which hTid-1(S) expression was down-regulated. We also found that overexpression of hTid-1(S) results in the inhibition of HSP27 phosphorylation, F-actin polymerization, and actin cytoskeleton organization in transduced HaCaT keratinocytes. This study further proposes that the loss of hTid-1(S) expression in the basal layer of skin epidermis correlates with the enhanced HSP27 phosphorylation, keratinocyte hyperproliferation, and excess actin cytoskeleton organization in lesional psoriatic skin. | - |
dc.language | English | - |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | - |
dc.subject | P38 MAP KINASE | - |
dc.subject | HYPOXIA-INDUCIBLE FACTORS | - |
dc.subject | HEAT-SHOCK PROTEIN-27 | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | CELL-MIGRATION | - |
dc.subject | ENDOTHELIAL-CELLS | - |
dc.subject | OXIDATIVE STRESS | - |
dc.subject | HUMAN HOMOLOG | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | ACTIVATION | - |
dc.title | Absence of a Human DnaJ Protein hTid-1(S) Correlates with Aberrant Actin Cytoskeleton Organization in Lesional Psoriatic Skin | - |
dc.type | Article | - |
dc.identifier.wosid | 000306916300023 | - |
dc.identifier.scopusid | 2-s2.0-84864386249 | - |
dc.type.rims | ART | - |
dc.citation.volume | 287 | - |
dc.citation.issue | 31 | - |
dc.citation.beginningpage | 25954 | - |
dc.citation.endingpage | 25963 | - |
dc.citation.publicationname | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.identifier.doi | 10.1074/jbc.M111.313809 | - |
dc.contributor.localauthor | Joe, Cheol-O | - |
dc.contributor.nonIdAuthor | Choi, Dae-Kyoung | - |
dc.contributor.nonIdAuthor | Sohn, Kyung-Cheol | - |
dc.contributor.nonIdAuthor | Lim, Jong-Soon | - |
dc.contributor.nonIdAuthor | Shin, In-Cheol | - |
dc.contributor.nonIdAuthor | Kim, Sung-Woo | - |
dc.contributor.nonIdAuthor | Lee, Jeung-Hoon | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | P38 MAP KINASE | - |
dc.subject.keywordPlus | HYPOXIA-INDUCIBLE FACTORS | - |
dc.subject.keywordPlus | HEAT-SHOCK PROTEIN-27 | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | CELL-MIGRATION | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | HUMAN HOMOLOG | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
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