DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Junil | ko |
dc.contributor.author | Choi, Minsoo | ko |
dc.contributor.author | Kim, Jeong-Rae | ko |
dc.contributor.author | Jin, Hua | ko |
dc.contributor.author | Kim, V. Narry | ko |
dc.contributor.author | Cho, Kwang-Hyun | ko |
dc.date.accessioned | 2013-03-13T02:14:34Z | - |
dc.date.available | 2013-03-13T02:14:34Z | - |
dc.date.created | 2012-11-29 | - |
dc.date.created | 2012-11-29 | - |
dc.date.issued | 2012-10 | - |
dc.identifier.citation | NUCLEIC ACIDS RESEARCH, v.40, no.18, pp.8849 - 8861 | - |
dc.identifier.issn | 0305-1048 | - |
dc.identifier.uri | http://hdl.handle.net/10203/104215 | - |
dc.description.abstract | The co-regulation of transcription factors (TFs) has been widely observed in various species. Why is such a co-regulation mechanism needed for transcriptional regulation? To answer this question, the following experiments and analyses were performed. First, examination of the human gene regulatory network (GRN) indicated that co-regulation was significantly enriched in the human GRN. Second, mathematical simulation of an artificial regulatory network showed that the co-regulation mechanism was related to the biphasic dose-response patterns of TFs. Third, the relationship between the co-regulation mechanism and the biphasic dose-response pattern was confirmed using microarray experiments examining different time points and different doses of the toxicant tetrachlorodibenzodioxin. Finally, two mathematical models were constructed to mimic highly co-regulated networks (HCNs) and little co-regulated networks (LCNs), and we found that HCNs were more robust to parameter perturbation than LCNs, whereas LCNs were faster in adaptation to environmental changes than HCNs. | - |
dc.language | English | - |
dc.publisher | OXFORD UNIV PRESS | - |
dc.subject | EVOLUTIONARY DESIGN PRINCIPLES | - |
dc.subject | EXPRESSION | - |
dc.subject | ROBUSTNESS | - |
dc.subject | PROFILES | - |
dc.subject | DATABASE | - |
dc.subject | SYSTEM | - |
dc.subject | MODULE | - |
dc.subject | ATLAS | - |
dc.subject | MOUSE | - |
dc.subject | YEAST | - |
dc.title | The co-regulation mechanism of transcription factors in the human gene regulatory network | - |
dc.type | Article | - |
dc.identifier.wosid | 000309927100015 | - |
dc.identifier.scopusid | 2-s2.0-84867524223 | - |
dc.type.rims | ART | - |
dc.citation.volume | 40 | - |
dc.citation.issue | 18 | - |
dc.citation.beginningpage | 8849 | - |
dc.citation.endingpage | 8861 | - |
dc.citation.publicationname | NUCLEIC ACIDS RESEARCH | - |
dc.identifier.doi | 10.1093/nar/gks664 | - |
dc.contributor.localauthor | Cho, Kwang-Hyun | - |
dc.contributor.nonIdAuthor | Kim, Jeong-Rae | - |
dc.contributor.nonIdAuthor | Jin, Hua | - |
dc.contributor.nonIdAuthor | Kim, V. Narry | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | EVOLUTIONARY DESIGN PRINCIPLES | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | ROBUSTNESS | - |
dc.subject.keywordPlus | PROFILES | - |
dc.subject.keywordPlus | DATABASE | - |
dc.subject.keywordPlus | SYSTEM | - |
dc.subject.keywordPlus | MODULE | - |
dc.subject.keywordPlus | ATLAS | - |
dc.subject.keywordPlus | MOUSE | - |
dc.subject.keywordPlus | YEAST | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.