One-pot facile synthesis of PEGylated Au nanoparticles in an aqueous media

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We describe a facile protocol for the synthesis of PEGylated Au nanoparticles by simply mixing aqueous solutions of HAuCl4 and oligo(ethylene glycol) ethyl ether methacrylate. This method was applied to generate uniform multiply-twinned Au nanostructures of similar to 21 nm in diameter with high yields. Our proposed mechanism indicates that the generation of primary alcohol intermediates from the nucleophilic addition reaction of water (nucleophile) with AuIII-vinyl complex is responsible for the reduction of gold ions. This protocol was also used to synthesize Ag nanoparticles and small aggregates of Pd nanoparticles. Due to the exclusion of sophisticated synthesis of PEG containing stabilizers, additional surfactants, or reducing agents, this approach provides a remarkably simple, versatile, and environmentally benign protocol to prepare PEGylated noble-metal nanocrystals. A comparative BSA adsorption study proved the lack of non-specific binding, a common obstacle in designing biocompatible nanoparticles. (c) 2012 Elsevier B.V. All rights reserved.
Publisher
ELSEVIER SCIENCE SA
Issue Date
2012-06
Language
English
Article Type
Article
Keywords

COATED GOLD NANOPARTICLES; DENDRIMER-STABILIZED GOLD; SILVER NANOPARTICLES; POLY(ETHYLENE GLYCOL); COLLOIDAL GOLD; DRUG-DELIVERY; ADSORPTION; SURFACE; PROTEINS; CANCER

Citation

MATERIALS CHEMISTRY AND PHYSICS, v.134, no.2-3, pp.1153 - 1159

ISSN
0254-0584
DOI
10.1016/j.matchemphys.2012.04.008
URI
http://hdl.handle.net/10203/104214
Appears in Collection
EEW-Journal Papers(저널논문)
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