Monodisperse Gas-Filled Microparticles from Reactions in Double Emulsions

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We present a strategy for preparing size-controlled gas-filled microparticles using two aqueous components that chemically react to produce the gas. We use a dual-bore microfluidic device to isolate the reactants of two gas-producing reactions until they are encapsulated in the outer droplet. The reactants in the monodisperse droplets merge and produce the gas bubbles, which are stabilized with a surfactant and form the core of the microparticles. The number and size of the generated gas bubbles are governed by the gas-forming reaction used. Our versatile strategy can be applied to a wide range of gas-producing reactions.
Publisher
AMER CHEMICAL SOC
Issue Date
2012-05
Language
English
Article Type
Article
Keywords

ULTRASOUND CONTRAST AGENTS; GENE DELIVERY-SYSTEM; MICROFLUIDIC FABRICATION; MICROBUBBLES; MICROSPHERES; SURFACTANTS; DRUG

Citation

LANGMUIR, v.28, no.17, pp.6742 - 6745

ISSN
0743-7463
DOI
10.1021/la300915p
URI
http://hdl.handle.net/10203/104154
Appears in Collection
CBE-Journal Papers(저널논문)
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