Viable capture and release of cancer cells in human whole blood

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We present viable cancer cell isolation devices utilizing the physical properties of cells. The tapered slit structure is proposed to isolate cancer cells from blood cells and collect them by reversed flow. From the experimental study using the spiked cancer cells in human whole blood, we verified the capability of the present cancer cell isolation chip in terms of capture efficiency, viability, and release rate. The viable cancer cells obtained from the present chip can be used for the further applications of cancer diagnosis, treatment monitoring, and new target drug development for cancer stem cells. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4737936]
Publisher
AMER INST PHYSICS
Issue Date
2012-07
Language
English
Article Type
Article
Keywords

CIRCULATING TUMOR-CELLS; BREAST-CANCER; PERIPHERAL-BLOOD; EPITHELIAL-CELLS; STEM-CELLS; DEVICE; IDENTIFICATION; ENUMERATION; RELEVANCE; SIZE

Citation

APPLIED PHYSICS LETTERS, v.101, no.4

ISSN
0003-6951
DOI
10.1063/1.4737936
URI
http://hdl.handle.net/10203/104053
Appears in Collection
BiS-Journal Papers(저널논문)
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