DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Myung-Joo | ko |
dc.contributor.author | Lee, Hyunseung | ko |
dc.contributor.author | Lee, Ju-Hee | ko |
dc.contributor.author | Jung, Kyung Hee | ko |
dc.contributor.author | Kim, Donghee | ko |
dc.contributor.author | Hong, Sungwoo | ko |
dc.contributor.author | Hong, Soon-Sun | ko |
dc.date.accessioned | 2013-03-12T23:38:18Z | - |
dc.date.available | 2013-03-12T23:38:18Z | - |
dc.date.created | 2012-07-19 | - |
dc.date.created | 2012-07-19 | - |
dc.date.issued | 2012-03 | - |
dc.identifier.citation | ARCHIVES OF PHARMACAL RESEARCH, v.35, no.4, pp.747 - 754 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.uri | http://hdl.handle.net/10203/103896 | - |
dc.description.abstract | Hepatocellular carcinoma (HCC) is one of the most common malignancies, yet there have been no significant advances in effective therapeutics. In this study, HS-111 was synthesized as a novel thiazolamine derivative, N-(5-(2-chlorobenzyl) thiazole-2-yl) benzofuran-2-carboxamide, and its anticancer effect and mechanism were examined in human HCC cells. HS-111 strongly suppressed the growth of HCC cells in a dose-dependent manner. Also, apoptosis by HS-111 was identified by DAPI and TUNEL staining, and the increases of the cleaved caspase-3 were observed. In addition, HS-111 decreased protein expression of hypoxia-inducible factor (HIF-1 alpha) and secretion of vascular endothelial growth factor (VEGF), and inhibited tube formation and the migration of human umbilical vein endothelial cells (HUVECs). These results showed that HS-111 not only inhibited cell growth and angiogenesis, but also induced apoptosis of human HCC cells. We suggest that HS-111 may be a potential candidate for chemotherapy against HCC. | - |
dc.language | English | - |
dc.publisher | PHARMACEUTICAL SOC KOREA | - |
dc.subject | BENZOFURAN DERIVATIVES | - |
dc.subject | BIOLOGICAL EVALUATION | - |
dc.subject | POTENT | - |
dc.subject | CANCER | - |
dc.subject | INHIBITORS | - |
dc.subject | MANAGEMENT | - |
dc.title | The effect of HS-111, a novel thiazolamine derivative, on apoptosis and angiogenesis of hepatocellular carcinoma cells | - |
dc.type | Article | - |
dc.identifier.wosid | 000303532800021 | - |
dc.identifier.scopusid | 2-s2.0-84862885984 | - |
dc.type.rims | ART | - |
dc.citation.volume | 35 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 747 | - |
dc.citation.endingpage | 754 | - |
dc.citation.publicationname | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.identifier.doi | 10.1007/s12272-012-0420-4 | - |
dc.contributor.localauthor | Hong, Sungwoo | - |
dc.contributor.nonIdAuthor | Choi, Myung-Joo | - |
dc.contributor.nonIdAuthor | Lee, Hyunseung | - |
dc.contributor.nonIdAuthor | Lee, Ju-Hee | - |
dc.contributor.nonIdAuthor | Jung, Kyung Hee | - |
dc.contributor.nonIdAuthor | Hong, Soon-Sun | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | HS-111 | - |
dc.subject.keywordAuthor | Thiazolamine | - |
dc.subject.keywordAuthor | HCC | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.subject.keywordAuthor | Angiogenesis | - |
dc.subject.keywordPlus | BENZOFURAN DERIVATIVES | - |
dc.subject.keywordPlus | BIOLOGICAL EVALUATION | - |
dc.subject.keywordPlus | POTENT | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | INHIBITORS | - |
dc.subject.keywordPlus | MANAGEMENT | - |
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