DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, Yun Hwa | ko |
dc.contributor.author | Kim, Ji Young | ko |
dc.contributor.author | Lee, Jeong Ho | ko |
dc.contributor.author | Chae, Hong Gu | ko |
dc.contributor.author | Jang, Sung Soo | ko |
dc.contributor.author | Jeon, Ju Hong | ko |
dc.contributor.author | Kim, Chul Hoon | ko |
dc.contributor.author | Kim, Jun | ko |
dc.contributor.author | Kim, Sang Jeong | ko |
dc.date.accessioned | 2013-03-12T23:13:22Z | - |
dc.date.available | 2013-03-12T23:13:22Z | - |
dc.date.created | 2012-10-14 | - |
dc.date.created | 2012-10-14 | - |
dc.date.issued | 2009-10 | - |
dc.identifier.citation | JOURNAL OF NEUROCHEMISTRY, v.111, no.1, pp.61 - 71 | - |
dc.identifier.issn | 0022-3042 | - |
dc.identifier.uri | http://hdl.handle.net/10203/103824 | - |
dc.description.abstract | Agonist-induced internalization of metabotropic glutamate receptors (mGluRs) plays an important role in neuronal signaling. Although internalization of mGluRs has been reported to be mediated by clathrin-dependent pathway, studies describing clathrin-independent pathways are emerging. Here, we report that agonist-induced internalization of mGluR1 alpha is mediated by caveolin. We show that two caveolin-binding motifs of mGluR1 alpha interact with caveolin1/2. Using cell surface-immunoprecipitation and total internal reflection fluorescence imaging, we found that agonist-induced internalization of mGluR1 alpha is regulated by caveolin-binding motifs of the receptor in heterologous cells. Moreover, in the cerebellum, group I mGluR agonist dihydroxyphenylglycol increased the interaction of phosphorylated caveolin with mGluR1 alpha. This interaction was blocked by methyl-beta-cyclodextrin, known to disrupt caveolin/caveolae-dependent signaling by cholesterol depletion. Methyl-beta-cyclodextrin also blocked the agonist-induced internalization of mGluR1 alpha. Thus, these findings represent the evidence for agonist-induced internalization of mGluR1 alpha via caveolin and suggest that caveolin might play a role in synaptic metaplasticity by regulating internalization of mGluR1 alpha in the cerebellum. | - |
dc.language | English | - |
dc.publisher | BLACKWELL PUBLISHING | - |
dc.subject | METABOTROPIC GLUTAMATE RECEPTORS | - |
dc.subject | LONG-TERM POTENTIATION | - |
dc.subject | PLASMA-MEMBRANE | - |
dc.subject | IN-VIVO | - |
dc.subject | TYPE-1-ALPHA RECEPTOR | - |
dc.subject | SCAFFOLDING DOMAIN | - |
dc.subject | ENDOTHELIAL-CELLS | - |
dc.subject | NUCLEUS-ACCUMBENS | - |
dc.subject | PROTEIN | - |
dc.subject | EXPRESSION | - |
dc.title | Agonist-induced internalization of mGluR1 alpha is mediated by caveolin | - |
dc.type | Article | - |
dc.identifier.wosid | 000269807900006 | - |
dc.identifier.scopusid | 2-s2.0-70349200667 | - |
dc.type.rims | ART | - |
dc.citation.volume | 111 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 61 | - |
dc.citation.endingpage | 71 | - |
dc.citation.publicationname | JOURNAL OF NEUROCHEMISTRY | - |
dc.identifier.doi | 10.1111/j.1471-4159.2009.06289.x | - |
dc.contributor.localauthor | Lee, Jeong Ho | - |
dc.contributor.nonIdAuthor | Hong, Yun Hwa | - |
dc.contributor.nonIdAuthor | Kim, Ji Young | - |
dc.contributor.nonIdAuthor | Chae, Hong Gu | - |
dc.contributor.nonIdAuthor | Jang, Sung Soo | - |
dc.contributor.nonIdAuthor | Jeon, Ju Hong | - |
dc.contributor.nonIdAuthor | Kim, Chul Hoon | - |
dc.contributor.nonIdAuthor | Kim, Jun | - |
dc.contributor.nonIdAuthor | Kim, Sang Jeong | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | agonist-induced internalization | - |
dc.subject.keywordAuthor | caveolin | - |
dc.subject.keywordAuthor | cerebellum | - |
dc.subject.keywordAuthor | mGluR1 alpha | - |
dc.subject.keywordPlus | METABOTROPIC GLUTAMATE RECEPTORS | - |
dc.subject.keywordPlus | LONG-TERM POTENTIATION | - |
dc.subject.keywordPlus | PLASMA-MEMBRANE | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | TYPE-1-ALPHA RECEPTOR | - |
dc.subject.keywordPlus | SCAFFOLDING DOMAIN | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | NUCLEUS-ACCUMBENS | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | EXPRESSION | - |
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