Targeted chemoimmunotherapy using drug-loaded aptamer-dendrimer bioconjugates

Cited 77 time in webofscience Cited 0 time in scopus
  • Hit : 351
  • Download : 0
We reported an innovative, targeted chemoimmuno drug-delivery system. Although chemoimmunotherapy, as an alternative to or in combination with conventional therapeutic systems, has been in the forefront of recent oncological research, as presently configured, such systems face several major obstacles for efficient clinical application. Here, we establish a novel nano-platform for effective chemoimmunotherapy designed to overcome the drawbacks of conventional cancer therapies, describing a delivery system based on a dendrimer and a single-strand DNA-A9 PSMA (prostate-specific membrane antigen) RNA aptamer hybrid. Employing these vehicles, we demonstrate the promising possibility of this chemoimmuno therapeutic system against prostate cancer in in vivo and in vitro models. (C) 2011 Elsevier B.V. All rights reserved.
Publisher
ELSEVIER SCIENCE BV
Issue Date
2011-11
Language
English
Article Type
Article
Keywords

CPG OLIGODEOXYNUCLEOTIDES; CANCER-CHEMOTHERAPY; DELIVERY; CELLS; LYMPHOMA; ANTIGEN; TUMORS

Citation

JOURNAL OF CONTROLLED RELEASE, v.155, no.3, pp.435 - 441

ISSN
0168-3659
DOI
10.1016/j.jconrel.2011.05.025
URI
http://hdl.handle.net/10203/103648
Appears in Collection
BS-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 77 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0