LTD induction suppresses LTP-induced hippocampal adult neurogenesis

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Neurogenesis persists in certain adult brain regions including the dentate gyrus. Recent studies have shown that long-term potentiation (LTP) induction in the afferent pathway enhances adult neurogenesis in the dentate gyrus. Here, we investigated whether long-term depression (LTD) induction also affects adult neurogenesis. We induced LTD in the dentate gyrus in one hemisphere and compared the amount of progenitor proliferation with that in the other hemisphere. Unlike LTP induction, LTD induction per se did not affect progenitor cell proliferation in the dentate gyrus. However, when LTD was induced a day before LTP induction, neuronal progenitor cell proliferation facilitated by LTP induction was markedly blunted. These results show that two forms of synaptic plasticity, LTP and LTD, differentially influence hippocampal adult neurogenesis. NeuroReport 20:1279-1283 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
Publisher
LIPPINCOTT WILLIAMS WILKINS
Issue Date
2009-09
Language
English
Article Type
Article
Keywords

LONG-TERM POTENTIATION; RAT DENTATE GYRUS; CELL-PROLIFERATION; PROGENITOR CELLS; DEPRESSION; STRESS; MECHANISMS; SYNAPSES; DEATH

Citation

NEUROREPORT, v.20, no.14, pp.1279 - 1283

ISSN
0959-4965
DOI
10.1097/WNR.0b013e3283303794
URI
http://hdl.handle.net/10203/103343
Appears in Collection
BS-Journal Papers(저널논문)
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