DC Field | Value | Language |
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dc.contributor.author | Won, Hong-Hee | ko |
dc.contributor.author | Lee, Jeeyun | ko |
dc.contributor.author | Park, Joon Oh | ko |
dc.contributor.author | Park, Young Suk | ko |
dc.contributor.author | Lim, Ho Yeong | ko |
dc.contributor.author | Kang, Won Ki | ko |
dc.contributor.author | Kim, Jong-Won | ko |
dc.contributor.author | Lee, Soo-Youn | ko |
dc.contributor.author | Park, Se Hoon | ko |
dc.date.accessioned | 2013-03-12T14:58:10Z | - |
dc.date.available | 2013-03-12T14:58:10Z | - |
dc.date.created | 2012-07-13 | - |
dc.date.created | 2012-07-13 | - |
dc.date.issued | 2012-06 | - |
dc.identifier.citation | CANCER, v.118, no.11, pp.2828 - 2836 | - |
dc.identifier.issn | 0008-543X | - |
dc.identifier.uri | http://hdl.handle.net/10203/102648 | - |
dc.description.abstract | BACKGROUND: To identify potential genetic markers for severe oxaliplatin-induced chronic peripheral neuropathy (OXCPN), the authors performed a genome-wide association analysis of patients with colon cancer who received oxaliplatin-based chemotherapy. METHODS: This was a prospective study in which DNA was purified in peripheral blood from patients with colon cancer who received oxaliplatin. The primary endpoint was the development of severe (grade 2 lasting for >7 days or grade 3) OXCPN. For the discovery set, genotyping was done for 96 patients who received adjuvant fluorouracil and oxaliplatin using the a genome-wide human single-nucleotide polymorphism (SNP) array. An association between polymorphisms and severe OXCPN was investigated. At the same time, 247 patients who received oxaliplatin-based, first-line chemotherapy for advanced disease were enrolled as a validation set. RESULTS: Among the 32 genotyped candidate SNPs selected from the discovery set, 9 SNPs in 8 genes (tachykinin, precursor 1[TAC1]; forkhead box C1 [FOXC1]; integrin, alpha 1 [ITGA1]; acylphosphatase 2, muscle type [ACYP2]; deleted in lymphocytic leukemia, 7 [DLEU7]; B-cell translocation gene 4 [BTG4]; calcium/calmodulin-dependent protein kinase II inhibitor 1 [CAMK2N1]; and phenylalanyl-tRNA synthase 2 [FARS2]) had nominal replication (P < .05). The most significant association was observed at reference SNP number (rs)10486003 in TAC1 (P = 4.84 x 10-7) in combined data from 2 sets. Five SNPs (rs10486003, rs2338, rs830884, rs843748, and rs797519) were significant in a multiple regression analysis (P < .05). Overall prediction accuracy calculated by the regression model was 72.8% (95% confidence interval, 65.8%-79.9%) in the model development and 75.9% (95% confidence interval, 66.9%-84.9%) in the model evaluation. CONCLUSIONS: The current results indicated that a genome-wide pharmacogenomic approach is useful for identifying novel polymorphism predictors of severe OXCPN that may be used in personalized chemotherapy. Cancer 2011 (c) 2011 American Cancer Society. | - |
dc.language | English | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.subject | ADVANCED COLORECTAL-CANCER | - |
dc.subject | FLUOROURACIL | - |
dc.subject | LEUCOVORIN | - |
dc.subject | CHEMOTHERAPY | - |
dc.subject | TRIAL | - |
dc.subject | PLUS | - |
dc.subject | PHARMACOGENOMICS | - |
dc.subject | TOXICITY | - |
dc.subject | PROTEINS | - |
dc.subject | THERAPY | - |
dc.title | Polymorphic markers associated with severe oxaliplatin-induced, chronic peripheral neuropathy in colon cancer patients | - |
dc.type | Article | - |
dc.identifier.wosid | 000304188700008 | - |
dc.identifier.scopusid | 2-s2.0-84861329544 | - |
dc.type.rims | ART | - |
dc.citation.volume | 118 | - |
dc.citation.issue | 11 | - |
dc.citation.beginningpage | 2828 | - |
dc.citation.endingpage | 2836 | - |
dc.citation.publicationname | CANCER | - |
dc.identifier.doi | 10.1002/cncr.26614 | - |
dc.contributor.nonIdAuthor | Lee, Jeeyun | - |
dc.contributor.nonIdAuthor | Park, Joon Oh | - |
dc.contributor.nonIdAuthor | Park, Young Suk | - |
dc.contributor.nonIdAuthor | Lim, Ho Yeong | - |
dc.contributor.nonIdAuthor | Kang, Won Ki | - |
dc.contributor.nonIdAuthor | Kim, Jong-Won | - |
dc.contributor.nonIdAuthor | Lee, Soo-Youn | - |
dc.contributor.nonIdAuthor | Park, Se Hoon | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | colon cancer | - |
dc.subject.keywordAuthor | genome-wide association | - |
dc.subject.keywordAuthor | neuropathy | - |
dc.subject.keywordAuthor | neurotoxicity | - |
dc.subject.keywordAuthor | oxaliplatin | - |
dc.subject.keywordAuthor | pharmacogenomics | - |
dc.subject.keywordPlus | ADVANCED COLORECTAL-CANCER | - |
dc.subject.keywordPlus | FLUOROURACIL | - |
dc.subject.keywordPlus | LEUCOVORIN | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordPlus | PLUS | - |
dc.subject.keywordPlus | PHARMACOGENOMICS | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | THERAPY | - |
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