DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jung, Seungmoon | ko |
dc.contributor.author | Seo, Jin Soo | ko |
dc.contributor.author | Kim, Byung Sun | ko |
dc.contributor.author | Lee, Doheon | ko |
dc.contributor.author | Jung, Keun-Hwa | ko |
dc.contributor.author | Chu, Kon | ko |
dc.contributor.author | Lee, Sang Kun | ko |
dc.contributor.author | Jeon, Daejong | ko |
dc.date.accessioned | 2013-03-12T12:41:53Z | - |
dc.date.available | 2013-03-12T12:41:53Z | - |
dc.date.created | 2012-10-09 | - |
dc.date.created | 2012-10-09 | - |
dc.date.issued | 2013-01 | - |
dc.identifier.citation | BEHAVIOURAL BRAIN RESEARCH, v.236, pp.23 - 29 | - |
dc.identifier.issn | 0166-4328 | - |
dc.identifier.uri | http://hdl.handle.net/10203/102358 | - |
dc.description.abstract | Atypical absence epilepsy (AAE) showing slow spike-and-wave discharges (SWD) is characterized by severely abnormal cognition and neurodevelopmental or neurological outcomes in humans. However, despite the severe behavioral outcomes in AAE, the relationship between AAE and social-behavioral dysfunctions has not defined well, either experimentally or in patients with AAE. Experimentally, AAE can be produced by administering AY-9944 (AY), a cholesterol biosynthesis inhibitor. In this study, we characterized social behavior in the AY mouse model of AAE. AAE in the mouse was induced by repeated postnatal administration of AY every 6 days from postnatal day (P) 2 to P20. AY-treated mice exhibited spontaneous, recurrent, and synchronous SWD (4-5 Hz) in electroencephalographic recordings. AY-treated mice performed tasks involving sociability/social novelty preference, social interaction with a juvenile conspecific, observational fear, and resident-intruder aggression. They showed behavioral dysfunction in social interactions with a juvenile conspecific and sociability/social novelty preference tasks. They also exhibited reduced social fear learning in observational fear conditioning. Interestingly, they showed increased levels of offensive behaviors in a resident-intruder task. However, AY-treated mice displayed normal levels of anxiety in light/dark transition and the elevated plus maze tasks, and showed slightly increased locomotor activity in an open-field task. These results demonstrate social dysfunction in the AY-induced AAE model. Our study of social behavior can also provide valuable information about Lennox-Gastaut syndrome, in which AAE is a component. Thus, our findings may help to understand behavioral pathogenesis or characteristics of patients with AAE. (c) 2012 Elsevier B.V. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | LENNOX-GASTAUT-SYNDROME | - |
dc.subject | SPIKE-WAVE DISCHARGES | - |
dc.subject | NETWORK MECHANISMS | - |
dc.subject | RAT MODEL | - |
dc.subject | SEIZURES | - |
dc.subject | MEMORY | - |
dc.subject | CHILDREN | - |
dc.subject | HIPPOCAMPUS | - |
dc.subject | BEHAVIOR | - |
dc.subject | MICE | - |
dc.title | Social deficits in the AY-9944 mouse model of atypical absence epilepsy | - |
dc.type | Article | - |
dc.identifier.wosid | 000310929400004 | - |
dc.identifier.scopusid | 2-s2.0-84865959199 | - |
dc.type.rims | ART | - |
dc.citation.volume | 236 | - |
dc.citation.beginningpage | 23 | - |
dc.citation.endingpage | 29 | - |
dc.citation.publicationname | BEHAVIOURAL BRAIN RESEARCH | - |
dc.identifier.doi | 10.1016/j.bbr.2012.08.029 | - |
dc.contributor.localauthor | Lee, Doheon | - |
dc.contributor.localauthor | Jeon, Daejong | - |
dc.contributor.nonIdAuthor | Jung, Seungmoon | - |
dc.contributor.nonIdAuthor | Seo, Jin Soo | - |
dc.contributor.nonIdAuthor | Kim, Byung Sun | - |
dc.contributor.nonIdAuthor | Jung, Keun-Hwa | - |
dc.contributor.nonIdAuthor | Chu, Kon | - |
dc.contributor.nonIdAuthor | Lee, Sang Kun | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Atypical absence epilepsy | - |
dc.subject.keywordAuthor | Behavioral comorbidities | - |
dc.subject.keywordAuthor | Social behavior | - |
dc.subject.keywordAuthor | AY-9944 | - |
dc.subject.keywordAuthor | Lennox-Gastaut syndrome | - |
dc.subject.keywordPlus | LENNOX-GASTAUT-SYNDROME | - |
dc.subject.keywordPlus | SPIKE-WAVE DISCHARGES | - |
dc.subject.keywordPlus | NETWORK MECHANISMS | - |
dc.subject.keywordPlus | RAT MODEL | - |
dc.subject.keywordPlus | SEIZURES | - |
dc.subject.keywordPlus | MEMORY | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | HIPPOCAMPUS | - |
dc.subject.keywordPlus | BEHAVIOR | - |
dc.subject.keywordPlus | MICE | - |
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