DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, Se-Woong | ko |
dc.contributor.author | Kim, Hye-Won | ko |
dc.contributor.author | Jun, Hong-Yeoung | ko |
dc.contributor.author | Park, Seong-Hoon | ko |
dc.contributor.author | Yoon, Kwon-Ha | ko |
dc.contributor.author | Kim, Hun-Soo | ko |
dc.contributor.author | Jon, Sangyong | ko |
dc.contributor.author | Yu, Mi Kyung | ko |
dc.contributor.author | Juhng, Seon-Kwan | ko |
dc.date.accessioned | 2013-03-12T11:03:31Z | - |
dc.date.available | 2013-03-12T11:03:31Z | - |
dc.date.created | 2012-07-09 | - |
dc.date.created | 2012-07-09 | - |
dc.date.issued | 2011-04 | - |
dc.identifier.citation | ACADEMIC RADIOLOGY, v.18, no.4, pp.504 - 511 | - |
dc.identifier.issn | 1076-6332 | - |
dc.identifier.uri | http://hdl.handle.net/10203/102099 | - |
dc.description.abstract | Rationale and Objectives: The aim of this study was to assess the feasibility of thermally cross-linked superparamagnetic iron oxide nanoparticle contrast (TCL-SPION) in magnetic resonance (MR) imaging (MRI) for the detection of lymph node metastasis in experimental model. Materials and Methods: B16F1 human melanoma cells were subcutaneously injected into the thighs of C57B116 mice (n = 10). MRI was performed 21 days after tumor injection using a 4.7-T MR scanner. In vivo MRI was performed before and after the intravenous administration of TCL-SPION using T2 fast spin-echo and T2 gradient-echo pulse sequences. Then, ex vivo MR images were obtained for resected inguinal lymph nodes (n = 18) using the same pulse sequences as for in vivo imaging. On the basis of hematoxylin and eosin staining results, the lymph nodes were classified into three groups: group 1, nonmetastatic; group 2, tumor volume < 50% of the resected sample; and group 3, tumor volume > 50% of the resected sample. Size, signal-to-background ratio, and enhancement pattern were evaluated in each of the three groups on ex vivo images. Results: The findings observed on ex vivo MR images of 18 inguinal lymph nodes were compared with histopathologic findings. All nodes were classified into three groups: group 1, n = 6; group 2, n = 5; and group 3, n = 7. The sizes of the lymph nodes in group 1 were significantly different from the sizes of those in group 3 (P = .014), but there was no significant difference in lymph node sizes between groups 1 and 2 (P = .792). Signal-to-background ratios of samples in groups 2 and 3 were significantly higher than those of samples in group 1 (P = .045 and P = .007, respectively). Each group of lymph nodes showed characteristic enhancement patterns that were well correlated between the images and pathology, except for one node. Conclusions: The features and extent of metastasis in the lymph nodes corresponded to those observed on TCL-SPION-enhanced MR images. TCL-SPION-enhanced MRI is useful for the detection and estimation of lymph node metastasis. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | SUPERPARAMAGNETIC IRON-OXIDE | - |
dc.subject | IN-VIVO | - |
dc.subject | CONTRAST AGENTS | - |
dc.subject | NANOPARTICLES | - |
dc.subject | CANCER | - |
dc.subject | PARTICLES | - |
dc.subject | FERUMOXTRAN-10 | - |
dc.subject | LYMPHOGRAPHY | - |
dc.subject | MELANOMA | - |
dc.subject | BEHAVIOR | - |
dc.title | TCL-SPION-enhanced MRI for the Detection of Lymph Node Metastasis in Murine Experimental Model | - |
dc.type | Article | - |
dc.identifier.wosid | 000288572200012 | - |
dc.identifier.scopusid | 2-s2.0-79952183324 | - |
dc.type.rims | ART | - |
dc.citation.volume | 18 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 504 | - |
dc.citation.endingpage | 511 | - |
dc.citation.publicationname | ACADEMIC RADIOLOGY | - |
dc.identifier.doi | 10.1016/j.acra.2010.10.017 | - |
dc.contributor.localauthor | Jon, Sangyong | - |
dc.contributor.nonIdAuthor | Lim, Se-Woong | - |
dc.contributor.nonIdAuthor | Kim, Hye-Won | - |
dc.contributor.nonIdAuthor | Jun, Hong-Yeoung | - |
dc.contributor.nonIdAuthor | Park, Seong-Hoon | - |
dc.contributor.nonIdAuthor | Yoon, Kwon-Ha | - |
dc.contributor.nonIdAuthor | Kim, Hun-Soo | - |
dc.contributor.nonIdAuthor | Yu, Mi Kyung | - |
dc.contributor.nonIdAuthor | Juhng, Seon-Kwan | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Lymph node | - |
dc.subject.keywordAuthor | metastases | - |
dc.subject.keywordAuthor | magnetic resonance | - |
dc.subject.keywordAuthor | MR | - |
dc.subject.keywordAuthor | contrast media | - |
dc.subject.keywordAuthor | iron | - |
dc.subject.keywordPlus | SUPERPARAMAGNETIC IRON-OXIDE | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | CONTRAST AGENTS | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | PARTICLES | - |
dc.subject.keywordPlus | FERUMOXTRAN-10 | - |
dc.subject.keywordPlus | LYMPHOGRAPHY | - |
dc.subject.keywordPlus | MELANOMA | - |
dc.subject.keywordPlus | BEHAVIOR | - |
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