Nanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs

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dc.contributor.authorKim, Deok-Hoko
dc.contributor.authorLipke, Elizabeth A.ko
dc.contributor.authorKim, Pilnamko
dc.contributor.authorCheong, Raymondko
dc.contributor.authorThompson, Susanko
dc.contributor.authorDelannoy, Michaelko
dc.contributor.authorSuh, Kahp-Yangko
dc.contributor.authorTung, Leslieko
dc.contributor.authorLevchenko, Andreko
dc.date.accessioned2013-03-12T10:37:49Z-
dc.date.available2013-03-12T10:37:49Z-
dc.date.created2012-07-13-
dc.date.created2012-07-13-
dc.date.issued2010-01-
dc.identifier.citationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.107, no.2, pp.565 - 570-
dc.identifier.issn0027-8424-
dc.identifier.urihttp://hdl.handle.net/10203/102052-
dc.description.abstractHeart tissue possesses complex structural organization on multiple scales, from macro- to nano-, but nanoscale control of cardiac function has not been extensively analyzed. Inspired by ultrastructural analysis of the native tissue, we constructed a scalable, nanotopographically controlled model of myocardium mimicking the in vivo ventricular organization. Guided by nanoscale mechanical cues provided by the underlying hydrogel, the tissue constructs displayed anisotropic action potential propagation and contractility characteristic of the native tissue. Surprisingly, cell geometry, action potential conduction velocity, and the expression of a cell-cell coupling protein were exquisitely sensitive to differences in the substratum nanoscale features of the surrounding extracellular matrix. We propose that controlling cell-material interactions on the nanoscale can stipulate structure and function on the tissue level and yield novel insights into in vivo tissue physiology, while providing materials for tissue repair.-
dc.languageEnglish-
dc.publisherNATL ACAD SCIENCES-
dc.subjectCELL-ADHESION-
dc.subjectMUSCLE-
dc.subjectORGANIZATION-
dc.subjectHYPERTROPHY-
dc.subjectFABRICATION-
dc.subjectTOPOGRAPHY-
dc.subjectANISOTROPY-
dc.subjectSCAFFOLDS-
dc.subjectSTRETCH-
dc.subjectMODEL-
dc.titleNanoscale cues regulate the structure and function of macroscopic cardiac tissue constructs-
dc.typeArticle-
dc.identifier.wosid000273559300011-
dc.identifier.scopusid2-s2.0-76249107098-
dc.type.rimsART-
dc.citation.volume107-
dc.citation.issue2-
dc.citation.beginningpage565-
dc.citation.endingpage570-
dc.citation.publicationnamePROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-
dc.identifier.doi10.1073/pnas.0906504107-
dc.contributor.localauthorKim, Pilnam-
dc.contributor.nonIdAuthorKim, Deok-Ho-
dc.contributor.nonIdAuthorLipke, Elizabeth A.-
dc.contributor.nonIdAuthorCheong, Raymond-
dc.contributor.nonIdAuthorThompson, Susan-
dc.contributor.nonIdAuthorDelannoy, Michael-
dc.contributor.nonIdAuthorSuh, Kahp-Yang-
dc.contributor.nonIdAuthorTung, Leslie-
dc.contributor.nonIdAuthorLevchenko, Andre-
dc.type.journalArticleArticle-
dc.subject.keywordAuthoraction potential-
dc.subject.keywordAuthorcardiomyocytes-
dc.subject.keywordAuthorextracellular matrix-
dc.subject.keywordAuthornanotopography-
dc.subject.keywordAuthortissue engineering-
dc.subject.keywordPlusCELL-ADHESION-
dc.subject.keywordPlusMUSCLE-
dc.subject.keywordPlusORGANIZATION-
dc.subject.keywordPlusHYPERTROPHY-
dc.subject.keywordPlusFABRICATION-
dc.subject.keywordPlusTOPOGRAPHY-
dc.subject.keywordPlusANISOTROPY-
dc.subject.keywordPlusSCAFFOLDS-
dc.subject.keywordPlusSTRETCH-
dc.subject.keywordPlusMODEL-
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