The BTB/POZ-ZF transcription factor dPLZF is involved in Ras/ERK signaling during wing development

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In , broad complex, tramtrack, bric A brac (BTB)/poxvirus and zinc finger (POZ) transcription factors are essential regulators of development. We searched the genome for BTB/POZ-ZF domains and discovered an unknown gene, , which encodes an orthologue of human . We then characterized the biological function of the via genetic interaction analysis. Ectopic expression of in the wing induced extra vein formation during wing development in . Genetic interactions between and Ras or extracellular signal-regulated kinase (ERK) significantly enhanced the formation of vein cells. On the other hand, loss-of-function mutations in resulted in a dramatic suppression of the extra and ectopic vein formation induced by elevated Ras/ERK signaling. Moreover, activity upregulated the expression of and , which perform crucial functions in vein cell formation in the developing wing. These results indicate that dPLZF is a transcription factor controlled by the Ras/ERK signaling pathway, which is a prominent regulator of vein cell formation during wing development in .
Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
Issue Date
2012-05
Language
English
Article Type
Article
Keywords

PROTEIN INTERACTION MOTIF; CAENORHABDITIS-ELEGANS; ECTOPIC EXPRESSION; TYROSINE KINASE; DROSOPHILA; RAS; DOMAIN; PATTERN; SPECIFICATION; LOCALIZATION

Citation

MOLECULES AND CELLS, v.33, no.5, pp.457 - 463

ISSN
1016-8478
DOI
10.1007/s10059-012-2179-3
URI
http://hdl.handle.net/10203/101835
Appears in Collection
MSE-Journal Papers(저널논문)
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