Blockade of VEGF-A suppresses tumor growth via inhibition of autocrine signaling through FAK and AKT

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Blockade of VEGF signaling using RNA interferences, a neutralizing antibody, an antagonizing soluble VEGF receptor, and a receptor tyrosine kinase inhibitor induced anti-tumor effects in human astrocytoma U251-MG and fibrosarcoma HT-1080 in vitro in a dose-dependent manner. Furthermore, blockade of VEGF-A using the doxycycline-inducible VEGF-A RNA interference system showed a significant antitumor effect in a murine HT-1080-xenograft model. Anti-tumor effect through the blockade of VEGF signaling was mediated by FAK and AKT pathway in vitro and in vivo. These results collectively indicate that VEGF-A and its receptors can act as key inducer of tumor growth as well as angiogenesis. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
Publisher
ELSEVIER IRELAND LTD
Issue Date
2012-05
Language
English
Article Type
Article
Citation

CANCER LETTERS, v.318, no.2, pp.221 - 225

ISSN
0304-3835
DOI
10.1016/j.canlet.2011.12.014
URI
http://hdl.handle.net/10203/101682
Appears in Collection
MSE-Journal Papers(저널논문)BiS-Journal Papers(저널논문)
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