DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.contributor.author | Park, Su-Hyung | ko |
dc.contributor.author | Demino, Mary | ko |
dc.contributor.author | Nascimbeni, M. | ko |
dc.contributor.author | Mihalik, Kathleen | ko |
dc.contributor.author | Major, Marian | ko |
dc.contributor.author | Veerapu, Naga S | ko |
dc.contributor.author | Heller, Theo | ko |
dc.contributor.author | Feinstone, S.M. | ko |
dc.contributor.author | Rice, Charles M | ko |
dc.contributor.author | Rehermann, B. | ko |
dc.date.accessioned | 2013-03-12T06:10:28Z | - |
dc.date.available | 2013-03-12T06:10:28Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2011-08 | - |
dc.identifier.citation | GASTROENTEROLOGY, v.141, no.2, pp.686 - 695 | - |
dc.identifier.issn | 0016-5085 | - |
dc.identifier.uri | http://hdl.handle.net/10203/101495 | - |
dc.description.abstract | BACKGROUND & AIMS: Hepatitis C virus (HCV) infection is characterized by lack of immune-mediated liver injury despite a high level of HCV replication during the incubation phase, which lasts about 8 weeks. We investigated whether this results from delayed recruitment of HCV-specific T cells and whether it facilitates HCV persistence. METHODS: Six chimpanzees were infected with HCV; blood and liver samples were collected for 28 weeks and analyzed for immune cells and chemokines. RESULTS: Two chimpanzees developed self-limited infections, whereas the remaining 4 developed chronic infections. Levels of the chemokines CXCL10, CXCL11, CCL4, and CCL5 increased in blood and liver samples from all chimpanzees within 1 month of HCV infection. Chemokine induction correlated with intrahepatic type I interferon (IFN) responses in vivo and was blocked by neutralizing antibodies against IFN-beta in vitro. Despite the early-stage induction of chemokines, the intrahepatic lymphocytic infiltrate started to increase no earlier than 8 weeks after HCV infection, when HCV-specific, tetramer-positive CD8(+) T cells appeared in the circulation. The HCV-specific CD8(+) T cells expressed chemokine receptors when they were initially detected in blood samples, so they could be recruited to the liver as soon as they entered the circulation. CONCLUSIONS: Chemokines are induced during early stages of HCV infection, which requires a type I IFN-mediated response. The delayed onset of acute hepatitis does not result from delayed recruitment of HCV-specific T cells, but could instead be related to a primary delay in the induction of HCV-specific T cells. Divergent outcomes occur without evident differences in chemokine induction and T-cell recruitment. | - |
dc.language | English | - |
dc.publisher | W.B. Saunders Ltd | - |
dc.title | Delayed induction, not impaired recruitment, of specific CD8 + T cells causes the late onset of acute hepatitis C | - |
dc.type | Article | - |
dc.identifier.wosid | 000293523300047 | - |
dc.identifier.scopusid | 2-s2.0-80051521537 | - |
dc.type.rims | ART | - |
dc.citation.volume | 141 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 686 | - |
dc.citation.endingpage | 695 | - |
dc.citation.publicationname | GASTROENTEROLOGY | - |
dc.identifier.doi | 10.1053/j.gastro.2011.05.006 | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.localauthor | Park, Su-Hyung | - |
dc.contributor.nonIdAuthor | Demino, Mary | - |
dc.contributor.nonIdAuthor | Nascimbeni, M. | - |
dc.contributor.nonIdAuthor | Mihalik, Kathleen | - |
dc.contributor.nonIdAuthor | Major, Marian | - |
dc.contributor.nonIdAuthor | Veerapu, Naga S | - |
dc.contributor.nonIdAuthor | Heller, Theo | - |
dc.contributor.nonIdAuthor | Feinstone, S.M. | - |
dc.contributor.nonIdAuthor | Rice, Charles M | - |
dc.contributor.nonIdAuthor | Rehermann, B. | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Liver Disease | - |
dc.subject.keywordAuthor | Virology | - |
dc.subject.keywordAuthor | Immune Response | - |
dc.subject.keywordAuthor | Monkey | - |
dc.subject.keywordPlus | VIRUS-INFECTION | - |
dc.subject.keywordPlus | GENOMIC ANALYSIS | - |
dc.subject.keywordPlus | HOST RESPONSE | - |
dc.subject.keywordPlus | B-VIRUS | - |
dc.subject.keywordPlus | LIVER | - |
dc.subject.keywordPlus | CHEMOKINE | - |
dc.subject.keywordPlus | LYMPHOCYTES | - |
dc.subject.keywordPlus | KINETICS | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordPlus | DISEASE | - |
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