DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, Jeong-Soo | ko |
dc.contributor.author | Greenlee, Kendra J. | ko |
dc.contributor.author | Pitchumani, Ramanan | ko |
dc.contributor.author | Lee, Seung-Hyo | ko |
dc.contributor.author | Song, Li-zhen | ko |
dc.contributor.author | Shan, Ming | ko |
dc.contributor.author | Chang, Seon Hee | ko |
dc.contributor.author | Park, Pyong Woo | ko |
dc.contributor.author | Dong, Chen | ko |
dc.contributor.author | Werb, Zena | ko |
dc.contributor.author | Bidani, Akhil | ko |
dc.contributor.author | Corry, David B. | ko |
dc.contributor.author | Kheradmand, Farrah | ko |
dc.date.accessioned | 2013-03-12T06:04:34Z | - |
dc.date.available | 2013-03-12T06:04:34Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2011-06 | - |
dc.identifier.citation | JOURNAL OF IMMUNOLOGY, v.186, no.11, pp.6427 - 6436 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | http://hdl.handle.net/10203/101488 | - |
dc.description.abstract | A localized and effective innate immune response to pathogenic bacterial invasion is central to host survival. Identification of the critical local innate mediators of lung defense against such pathogens is essential for a complete understanding of the mechanism(s) underlying effective host defense. In an acute model of Streptococcus pneumoniae lung infection, deficiency in matrix metalloproteinase (MMP)2 and MMP9 (Mmp2/9(-/-)) conferred a survival disadvantage relative to wild-type mice treated under the same conditions. S. pneumoniae-infected Mmp2/9(-/-) mice recruited more polymorphonuclear leukocytes to the lung but had higher bacterial burdens. Mmp2/9(-/-) mice showed significantly higher levels of IL-17A, IP-10, and RANTES in the lung. Although MMP2-dependent cleavage partially inactivated IL-17A, MMP9 was critical for effective bacterial phagocytosis and reactive oxygen species generation in polymorphonuclear neutrophils. These data demonstrate critical nonredundant and protective roles for MMP2 and MMP9 in the early host immune response against S. pneumoniae infection. The Journal of Immunology, 2011, 186: 6427-6436. | - |
dc.language | English | - |
dc.publisher | AMER ASSOC IMMUNOLOGISTS | - |
dc.subject | INFLAMMATORY CELL EGRESSION | - |
dc.subject | TISSUE INFLAMMATION | - |
dc.subject | HUMAN NEUTROPHILS | - |
dc.subject | HOST-DEFENSE | - |
dc.subject | IN-VIVO | - |
dc.subject | VIRULENCE | - |
dc.subject | PROTEINS | - |
dc.subject | LUNG | - |
dc.subject | INTERLEUKIN-17 | - |
dc.subject | SUSCEPTIBILITY | - |
dc.title | Dual Protective Mechanisms of Matrix Metalloproteinases 2 and 9 in Immune Defense against Streptococcus pneumoniae | - |
dc.type | Article | - |
dc.identifier.wosid | 000290755700042 | - |
dc.identifier.scopusid | 2-s2.0-79958032102 | - |
dc.type.rims | ART | - |
dc.citation.volume | 186 | - |
dc.citation.issue | 11 | - |
dc.citation.beginningpage | 6427 | - |
dc.citation.endingpage | 6436 | - |
dc.citation.publicationname | JOURNAL OF IMMUNOLOGY | - |
dc.contributor.localauthor | Lee, Seung-Hyo | - |
dc.contributor.nonIdAuthor | Hong, Jeong-Soo | - |
dc.contributor.nonIdAuthor | Greenlee, Kendra J. | - |
dc.contributor.nonIdAuthor | Pitchumani, Ramanan | - |
dc.contributor.nonIdAuthor | Song, Li-zhen | - |
dc.contributor.nonIdAuthor | Shan, Ming | - |
dc.contributor.nonIdAuthor | Chang, Seon Hee | - |
dc.contributor.nonIdAuthor | Park, Pyong Woo | - |
dc.contributor.nonIdAuthor | Dong, Chen | - |
dc.contributor.nonIdAuthor | Werb, Zena | - |
dc.contributor.nonIdAuthor | Bidani, Akhil | - |
dc.contributor.nonIdAuthor | Corry, David B. | - |
dc.contributor.nonIdAuthor | Kheradmand, Farrah | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | INFLAMMATORY CELL EGRESSION | - |
dc.subject.keywordPlus | TISSUE INFLAMMATION | - |
dc.subject.keywordPlus | HUMAN NEUTROPHILS | - |
dc.subject.keywordPlus | HOST-DEFENSE | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | VIRULENCE | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | LUNG | - |
dc.subject.keywordPlus | INTERLEUKIN-17 | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.