Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection

Cited 127 time in webofscience Cited 0 time in scopus
  • Hit : 448
  • Download : 0
Although mucosal surfaces represent the main portal of entry for pathogens, the mechanism of antigen presentation by dendritic cells (DCs) that patrol various mucosal tissues remains unclear. Instead, much effort has focused on the understanding of initiation of immune responses generated against antigens delivered by injection. We examined the contributions of migratory versus lymph node-resident DC populations in antigen presentation to CD4 and CD8 T cells after needle injection, epicutaneous infection, or vaginal mucosal herpes simplex virus (HSV) 1 infection. We show that upon needle injection, HSV-1 became lymph-borne and was rapidly presented by lymph node-resident DCs to CD4 and CD8 T cells. In contrast, after vaginal HSV-1 infection, antigens were largely presented by tissue-derived migrant DCs with delayed kinetics. In addition, migrant DCs made more frequent contact with HSV-specific T cells after vaginal infection compared with epicutaneous infection. Thus, both migrant and resident DCs play an important role in priming CD8 and CD4 T cell responses, and their relative importance depends on the mode of infection in vivo.
Publisher
ROCKEFELLER UNIV PRESS
Issue Date
2009-02
Language
English
Article Type
Article
Keywords

HERPES-SIMPLEX-VIRUS; CD8-ALPHA(+) DENDRITIC CELLS; DRAINING LYMPH-NODE; SUBSETS IN-VIVO; LANGERHANS CELLS; ANTIGEN PRESENTATION; CUTTING EDGE; STEADY-STATE; LIFE-SPAN; IMMUNITY

Citation

JOURNAL OF EXPERIMENTAL MEDICINE, v.206, no.2, pp.359 - 370

ISSN
0022-1007
DOI
10.1084/jem.20080601
URI
http://hdl.handle.net/10203/101444
Appears in Collection
MSE-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 127 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0