DC Field | Value | Language |
---|---|---|
dc.contributor.author | Adachi, Hironori | ko |
dc.contributor.author | Kondo, Tatsuya | ko |
dc.contributor.author | Koh, Gou Young | ko |
dc.contributor.author | Nagy, Andras | ko |
dc.contributor.author | Oike, Yuichi | ko |
dc.contributor.author | Araki, Eiichi | ko |
dc.date.accessioned | 2013-03-12T03:51:34Z | - |
dc.date.available | 2013-03-12T03:51:34Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2011-06 | - |
dc.identifier.citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.409, no.2, pp.177 - 180 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | http://hdl.handle.net/10203/101250 | - |
dc.description.abstract | Angiopoietin-like protein family 4 (Angptl4) has been shown to regulate lipoprotein metabolism through the inhibition of lipoprotein lipase (LPL). In familial hypercholesterolemia (FH), individuals lacking low-density lipoprotein receptor (LDLR) present not only hypercholesterolemia, but also increased plasma triglyceride (TG)-rich lipoprotein remnants, and develop atherosclerosis. In addition, the most common type of dyslipidemia in individuals with diabetes is increased TG levels. We first generated LDLR(-/-)Angptl4(-/-) mice to study the effect of Angptl4 deficiency on the lipid metabolism. Fasting total cholesterol, VLDL-C, LDL-C, HDL-C and TG levels were decreased in LDLR(-/-) Angptl4(-/-) mice compared with LDLR(-/-) Angptl4(+/+) mice. In particular, post olive oil-loaded TG excursion were largely attenuated in LDLR(-/-)Angptl4(-/-) mice compared with LDLR(-/-)Angptl4(+/+) mice. We next introduced diabetes by streptozotocin (STZ) treatment in Angptl4(-/-) mice and examined the impacts of Angptl4 deficiency. Compared with diabetic Angptl4(+/+) mice, diabetic Angptl4(-/-) mice showed the improvement of fasting and postprandial hypertriglyceridemia as well. Thus, targeted silencing of Angptl4 offers a potential therapeutic strategy for the treatment of dyslipidemia in individuals with FH and insulin deficient diabetes. (C) 2011 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | ANGIOPOIETIN-LIKE PROTEIN-4 | - |
dc.subject | FAMILIAL HYPERCHOLESTEROLEMIA | - |
dc.subject | ADIPOSE-TISSUE | - |
dc.subject | LIPASE | - |
dc.subject | METABOLISM | - |
dc.subject | LIPEMIA | - |
dc.title | Angptl4 deficiency decreases serum triglyceride levels in low-density lipoprotein receptor knockout mice and streptozotocin-induced diabetic mice | - |
dc.type | Article | - |
dc.identifier.wosid | 000291779100005 | - |
dc.identifier.scopusid | 2-s2.0-79957895547 | - |
dc.type.rims | ART | - |
dc.citation.volume | 409 | - |
dc.citation.issue | 2 | - |
dc.citation.beginningpage | 177 | - |
dc.citation.endingpage | 180 | - |
dc.citation.publicationname | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.contributor.localauthor | Koh, Gou Young | - |
dc.contributor.nonIdAuthor | Adachi, Hironori | - |
dc.contributor.nonIdAuthor | Kondo, Tatsuya | - |
dc.contributor.nonIdAuthor | Nagy, Andras | - |
dc.contributor.nonIdAuthor | Oike, Yuichi | - |
dc.contributor.nonIdAuthor | Araki, Eiichi | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Diabetes mellitus | - |
dc.subject.keywordAuthor | Familial hypercholesterolemia | - |
dc.subject.keywordAuthor | Lipoprotein lipase | - |
dc.subject.keywordAuthor | Postprandial hypertriglyceridemia | - |
dc.subject.keywordAuthor | Angptl4 | - |
dc.subject.keywordPlus | ANGIOPOIETIN-LIKE PROTEIN-4 | - |
dc.subject.keywordPlus | FAMILIAL HYPERCHOLESTEROLEMIA | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | LIPASE | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | LIPEMIA | - |
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