DC Field | Value | Language |
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dc.contributor.author | Cho, Kyung-Hee | ko |
dc.contributor.author | Kwon, Sun U. | ko |
dc.contributor.author | Lee, Deok Hee | ko |
dc.contributor.author | Shim, WooHyun | ko |
dc.contributor.author | Choi, ChoongGon | ko |
dc.contributor.author | Kim, Sang Joon | ko |
dc.contributor.author | Suh, Dae-Chul | ko |
dc.contributor.author | Kim, Jong S. | ko |
dc.contributor.author | Kang, Dong-Wha | ko |
dc.date.accessioned | 2013-03-12T03:12:57Z | - |
dc.date.available | 2013-03-12T03:12:57Z | - |
dc.date.created | 2012-05-31 | - |
dc.date.created | 2012-05-31 | - |
dc.date.issued | 2012-05 | - |
dc.identifier.citation | JOURNAL OF THE NEUROLOGICAL SCIENCES, v.316, no.1-2, pp.99 - 103 | - |
dc.identifier.issn | 0022-510X | - |
dc.identifier.uri | http://hdl.handle.net/10203/101172 | - |
dc.description.abstract | Background: Ischemic lesion growth may be a surrogate marker of clinical outcome, but no such interrelationship after thrombolysis has yet been determined. We evaluated the association between early infarct growth on diffusion-weighted imaging (DWI) and long-term clinical outcome after thrombolysis. Methods: We retrospectively reviewed outcomes in patients with acute middle cerebral artery territory stroke who had been treated with intravenous tissue plasminogen activator or intra-arterial urokinase. DWI lesion volumes were measured at baseline and within 7 days. and the difference was calculated. Clinical outcome was evaluated using the modified Rankin Scale (mRS) at 3 months. Good and poor clinical outcomes were defined as: a) mRS 0-1 vs. mRS 2-6, b) mRS 0-2 vs. mRS 3-6, and c) responder analysis which was influenced by the baseline National Institutes of Health Stroke Scale (NIHSS) scores: good and poor outcomes were defined as mRS 0 vs. mRS 1-6 if the baseline NIHSS score was < 8, mRS 0-1 vs. mRS 2-6 if the NIHSS score was 8-14, and mRS 0-2 vs. mRS 3-6 if the NIHSS score was > 14. The relationship between the ischemic lesion volume change and clinical outcome was explored. The cut-off value of infarct growth predicting long-term outcome was estimated using receiver operating characteristic analysis. Results: Of the 81 patients included, 67 (82.7%) showed lesion growth, and absolute growth was significantly related to poor outcomes (P < 0.001 all for mRS 2-6, mRS 3-6, and responder analysis). Multivariate analysis showed that absolute lesion growth was an independent predictor of poor outcome, defined as mRS 2-6 (P = 0.002; odds ratio [OR], 1.06; 95% confidence interval [CI], 1.02-1.10), mRS 3-6 (P = 0.001; OR, 1.06; 95% CI, 1.02-1.10), and poor outcome by responder analysis (P = 0.001; OR, 1.06; 95% CI, 1.03-1.10). The cut-off values of lesion growth that discriminated between good and poor outcomes were 14.11 cm(3) for mRS 2-6; 15.87 cm(3) for mRS 3-6; and 14.11 cm(3) in responder analysis. Conclusions: Early DWI lesion growth is an independent predictor of poor outcome after thrombolysis and may serve a potential surrogate marker of clinical outcome in acute stroke trials. (C) 2012 Elsevier BM. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.subject | ACUTE ISCHEMIC-STROKE | - |
dc.subject | TISSUE-PLASMINOGEN ACTIVATOR | - |
dc.subject | LESION VOLUME | - |
dc.subject | INDEPENDENT PREDICTOR | - |
dc.subject | 3 H | - |
dc.subject | DIFFUSION | - |
dc.subject | TRIAL | - |
dc.subject | MRI | - |
dc.subject | DESMOTEPLASE | - |
dc.subject | EVOLUTION | - |
dc.title | Early infarct growth predicts long-term clinical outcome after thrombolysis | - |
dc.type | Article | - |
dc.identifier.wosid | 000303177900018 | - |
dc.identifier.scopusid | 2-s2.0-84862789540 | - |
dc.type.rims | ART | - |
dc.citation.volume | 316 | - |
dc.citation.issue | 1-2 | - |
dc.citation.beginningpage | 99 | - |
dc.citation.endingpage | 103 | - |
dc.citation.publicationname | JOURNAL OF THE NEUROLOGICAL SCIENCES | - |
dc.identifier.doi | 10.1016/j.jns.2012.01.015 | - |
dc.contributor.nonIdAuthor | Cho, Kyung-Hee | - |
dc.contributor.nonIdAuthor | Kwon, Sun U. | - |
dc.contributor.nonIdAuthor | Lee, Deok Hee | - |
dc.contributor.nonIdAuthor | Choi, ChoongGon | - |
dc.contributor.nonIdAuthor | Kim, Sang Joon | - |
dc.contributor.nonIdAuthor | Suh, Dae-Chul | - |
dc.contributor.nonIdAuthor | Kim, Jong S. | - |
dc.contributor.nonIdAuthor | Kang, Dong-Wha | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Acute stroke | - |
dc.subject.keywordAuthor | Outcome | - |
dc.subject.keywordAuthor | Diffusion-weighted imaging | - |
dc.subject.keywordAuthor | MRI | - |
dc.subject.keywordAuthor | Thrombolysis | - |
dc.subject.keywordPlus | ACUTE ISCHEMIC-STROKE | - |
dc.subject.keywordPlus | TISSUE-PLASMINOGEN ACTIVATOR | - |
dc.subject.keywordPlus | LESION VOLUME | - |
dc.subject.keywordPlus | INDEPENDENT PREDICTOR | - |
dc.subject.keywordPlus | 3 H | - |
dc.subject.keywordPlus | DIFFUSION | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordPlus | MRI | - |
dc.subject.keywordPlus | DESMOTEPLASE | - |
dc.subject.keywordPlus | EVOLUTION | - |
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