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College of Life Science and Bioengineering(생명과학기술대학)Dept. of Biological Sciences(생명과학과)BS-Journal Papers(저널논문)

Pluronic/Polyethylenimine Shell Cross linked Nanocapsules with Embedded Magnetite Nanocrystals for Magnetically Triggered Delivery of siRNA

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dc.contributor.authorLee, Kyu-Riko
dc.contributor.authorBae, Ki-Hyunko
dc.contributor.authorLee, Yu-Hanko
dc.contributor.authorLee, Soo-Hyeonko
dc.contributor.authorAhn, Cheol-Heeko
dc.contributor.authorPark, Tae-Gwanko
dc.date.accessioned2013-03-11T22:11:13Z-
dc.date.available2013-03-11T22:11:13Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2010-03-
dc.identifier.citationMACROMOLECULAR BIOSCIENCE, v.10, no.3, pp.239 - 245-
dc.identifier.issn1616-5187-
dc.identifier.urihttp://hdl.handle.net/10203/100458-
dc.description.abstractPluronic/polyethylenimine shell crosslinked nanocapsules with embedded magnetite nanocrystals (PPMCs) were developed for magnetically triggered delivery of siRNA. The positively charged PPMCs formed stable nanosized polyelectrolyte complexes via electrostatic interactions with negatively charged siRNA-polyethylene glycol conjugate (siRNA-s-s-PEG) that was linked via a cleavable disulfide linkage. PPMC/siRNA-s-s-PEG polyelectrolyte complexes were efficiently taken up by cancer cells upon exposure to a magnet, thereby enhancing intracellular uptake and silencing effect of siRNA. The present study suggests that these novel nanomaterials could be potentially utilized for magnetically triggered delivery of various nucleic acid-based therapeutic agents.-
dc.languageEnglish-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.subjectIRON-OXIDE NANOPARTICLES-
dc.subjectPOLYELECTROLYTE COMPLEX MICELLES-
dc.subjectVEGF SIRNA-
dc.subjectGOLD NANOPARTICLES-
dc.subjectMAMMALIAN-CELLS-
dc.subjectDRUG-DELIVERY-
dc.subjectCANCER-
dc.subjectRNA-
dc.subjectDISRUPTION-
dc.subjectPOLYMERS-
dc.titlePluronic/Polyethylenimine Shell Cross linked Nanocapsules with Embedded Magnetite Nanocrystals for Magnetically Triggered Delivery of siRNA-
dc.typeArticle-
dc.identifier.wosid000276138200002-
dc.identifier.scopusid2-s2.0-77749292523-
dc.type.rimsART-
dc.citation.volume10-
dc.citation.issue3-
dc.citation.beginningpage239-
dc.citation.endingpage245-
dc.citation.publicationnameMACROMOLECULAR BIOSCIENCE-
dc.identifier.doi10.1002/mabi.200900291-
dc.contributor.localauthorPark, Tae-Gwan-
dc.contributor.nonIdAuthorAhn, Cheol-Hee-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorbiomaterials-
dc.subject.keywordAuthorcomposites-
dc.subject.keywordAuthordrug delivery systems-
dc.subject.keywordAuthornanotechnology-
dc.subject.keywordAuthorpolyelectrolytes-
dc.subject.keywordPlusIRON-OXIDE NANOPARTICLES-
dc.subject.keywordPlusPOLYELECTROLYTE COMPLEX MICELLES-
dc.subject.keywordPlusVEGF SIRNA-
dc.subject.keywordPlusGOLD NANOPARTICLES-
dc.subject.keywordPlusMAMMALIAN-CELLS-
dc.subject.keywordPlusDRUG-DELIVERY-
dc.subject.keywordPlusCANCER-
dc.subject.keywordPlusRNA-
dc.subject.keywordPlusDISRUPTION-
dc.subject.keywordPlusPOLYMERS-
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