DSpace Community: KAIST Dept. of Chemical and Biomolecular EngineeringKAIST Dept. of Chemical and Biomolecular Engineeringhttp://hdl.handle.net/10203/172024-03-07T03:22:43Z2024-03-07T03:22:43ZSystems metabolic engineering for the production of pharmaceutical natural productsZhou, HengruiEun, HyunminLee, Sang Yuphttp://hdl.handle.net/10203/3165572023-12-18T02:00:19Z2024-03-01T00:00:00ZTitle: Systems metabolic engineering for the production of pharmaceutical natural products
Authors: Zhou, Hengrui; Eun, Hyunmin; Lee, Sang Yup
Abstract: The increased awareness of the pharmaceutical supply chain issues after the recent pandemic crisis has emphasized the need for innovative drug discovery. Natural products (NPs) have emerged as promising candidates to address pandemics due to their diverse structures and medicinal properties. However, development of novel NP-drugs in pharmaceutical supply chains has faced many challenges, including the absence of an efficient large-scale production platform to meet market demands. The advent of systems metabolic engineering has facilitated the efficient production of NPs in microorganisms compared with traditional plant-based and chemical-based production. In this article, we review recent strategies in systems metabolic engineering that have opened up new avenues for NP-drug discovery and production. In addition, we suggest viewpoints on how combinatorial approaches of systems metabolic engineering and synthetic chemistry will further enhance the diversity of NP-drugs and provide prospects for the development of NP-drugs in the pharmaceutical supply chain.2024-03-01T00:00:00ZPolymer donors with hydrophilic side-chains enabling efficient and thermally-stable polymer solar cells by non-halogenated solvent processingSeo, SoodeokPark, Jun-YoungPark, Jin SuLee, SeungjinChoi, Do-YeongKim, Yun-HiKim, Bumjoon J.http://hdl.handle.net/10203/3172742024-01-03T05:00:30Z2024-03-01T00:00:00ZTitle: Polymer donors with hydrophilic side-chains enabling efficient and thermally-stable polymer solar cells by non-halogenated solvent processing
Authors: Seo, Soodeok; Park, Jun-Young; Park, Jin Su; Lee, Seungjin; Choi, Do-Yeong; Kim, Yun-Hi; Kim, Bumjoon J.
Abstract: Polymer solar cells (PSCs) with high power conversion efficiency (PCE) and environment-friendly fabrication are the main requirements enabling their production in industrial scale. While the use of non-halogenated solvent processing is inevitable for the PSC fabrication, it significantly reduces the processability of polymer donors (PDS) and small-molecule acceptors (SMAs). This often results in unoptimized blend morphology and limits the device performance. To address this issue, hydrophilic oligoethylene glycol (OEG) side-chains are introduced into a PD (2EG) to enhance the molecular compatibility between the PD and L8-BO SMA. The 2EG PD induces higher crystallinity and alleviates phase separation with the SMA compared to the reference PD (PM7) with hydrocarbon side-chains. Consequently, the 2EG-based PSCs exhibit a higher PCE (15.8%) than the PM7-based PSCs (PCE = 14.4%) in the ortho-xylene based processing. Importantly, benefitted from the reduced phase separation and increased crystallinity of 2EG PDS, the 2EG-based PSCs show enhanced thermal stability (84% of initial PCE after 120 h heating) compared to that of the PM7-based PSCs (60% of initial PCE after 120 h heating). This study demonstrates the potential of OEG side-chain-incorporated materials in developing efficient, stable, and eco-friendly PSCs.2024-03-01T00:00:00ZThe 19th Korea-Japan symposium on catalysis (19th KJSC)Roh, Hyun-SeogChoi, JungkyuChoi, MinkeeKatada, Naonobuhttp://hdl.handle.net/10203/3174782024-01-08T03:00:21Z2024-03-01T00:00:00ZTitle: The 19th Korea-Japan symposium on catalysis (19th KJSC)
Authors: Roh, Hyun-Seog; Choi, Jungkyu; Choi, Minkee; Katada, Naonobu2024-03-01T00:00:00ZMechanistic study of oxygen reduction reaction on a Pd/CeO2-ZrO2 catalystYou, Hyo MinNagasawa, TsuyoshiLee, Jae WooKwon, HyungukKim, Kyeounghakhttp://hdl.handle.net/10203/3177642024-01-11T08:00:15Z2024-03-01T00:00:00ZTitle: Mechanistic study of oxygen reduction reaction on a Pd/CeO2-ZrO2 catalyst
Authors: You, Hyo Min; Nagasawa, Tsuyoshi; Lee, Jae Woo; Kwon, Hyunguk; Kim, Kyeounghak
Abstract: Three-way catalysts (TWCs) are widely used to convert the exhaust gases produced by internal combustion engines, including hydrocarbons, CO, and NOx, into harmless gases such as CO2, N2, and H2O. TWCs mainly consist of a metal catalyst, catalyst support, and ceramic substrate, and their performance is known to be closely related to the oxygen storage capacity (OSC) of the ceramic substrates. However, oxygen storage is a complex multi-step process that is not yet fully understood. In this study, we visualized oxygen storage at the Pd/CeO2–ZrO2 (CZ) interface in the practical operating temperature range of TWCs using oxygen isotope quench techniques and elucidated the detailed reaction mechanism using density functional theory calculations. Pd supported on CZ promotes the incorporation of oxygen into the CZ surface. In addition, our investigation of the transport behavior of the incorporated oxygen in the bulk regime reveals that the bond strength between oxygen and surrounding atoms is weakened by Zr doping, resulting in more facile oxygen vacancy formation and oxygen migration. Our results provide useful insights that will guide the future design of highly active TWCs.2024-03-01T00:00:00Z