Researcher Page

사진

Lee, Gyun Min (이균민) C-2020-2011

Department
Department of Biological Sciences(생명과학과)
Co-author
Collaboration Network Collaboration Network
Website
http://bs.kaist.ac.kr/~acelab/HomePage
Research Area
Proteomics, Cell engineering, Bio-reactor (Fed-batch, Perfusion culture)

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1

Improving recombinant bone morphogenetic protein-4 (BMP-4) production by autoregulatory feedback loop removal using BMP receptor-knockout CHO cell lines

Kim, Che Lin; Lee, Gyun MinresearcherACADEMIC PRESS INC ELSEVIER SCIENCEMETABOLIC ENGINEERING, v.52, pp.57 - 67, 2019-03

2

Glyco-engineered CHO cell lines producing alpha-1-antitrypsin and C1 esterase inhibitor with fully humanized N-glycosylation profiles

Amann, Thomas; Hansen, Anders Holmgaard; Kol, Stefan; Hansen, Henning Gram; Arnsdorf, Johnny; Nallapareddy, Saranya; Voldborg, Bjorn; Lee, Gyun Minresearcher; Andersen, Mikael Rordam; Kildegaard, Helene FaustrupACADEMIC PRESS INC ELSEVIER SCIENCEMETABOLIC ENGINEERING, v.52, pp.143 - 152, 2019-03

3

Revealing Key Determinants of Clonal Variation in Transgene Expression in Recombinant CHO Cells Using Targeted Genome Editing

Jae Seong Lee; Park, Jin-Hyoung; Ha, Tae Kwang; Samoudi, Mojtaba; Lewis, Nathan E.; Palsson, Bernhard O.; Kildegaard, Helene Faustrup; Lee, Gyun MinresearcherAMER CHEMICAL SOCACS SYNTHETIC BIOLOGY, v.7, no.12, pp.2867 - 2878, 2018-12

4

Improving the production of recombinant human bone morphogenetic protein-4 in Chinese hamster ovary cell cultures by inhibition of undesirable endocytosis

Kim, Che Lin; Jung, Mi Yeong; Kim, Young Sik; Jang, Ju Woong; Lee, Gyun MinresearcherWILEYBIOTECHNOLOGY AND BIOENGINEERING, v.115, no.10, pp.2565 - 2575, 2018-10

5

CRISPR/Cas9-Multiplexed Editing of Chinese Hamster Ovary B4Gal-T1, 2, 3, and 4 Tailors N-Glycan Profiles of Therapeutics and Secreted Host Cell Proteins

Amann, Thomas; Hansen, Anders Holmgaard; Kol, Stefan; Lee, Gyun Minresearcher; Andersen, Mikael Rordam; Kildegaard, Helene FaustrupWILEY-V C H VERLAG GMBHBIOTECHNOLOGY JOURNAL, v.13, no.10, 2018-10

6

Differential expression of microRNAs in recombinant Chinese hamster ovary cells treated with sodium butyrate using digital RNA counting

Lim, Sung-Min; Park, Sun-Hye; Lee, Joohyoung; Kim, Sun Hong; Kim, Jee-Yon; Min, Jeong-Ki; Lee, Gyun Minresearcher; Kim, Yeon-GuELSEVIER SCIENCE BVJOURNAL OF BIOTECHNOLOGY, v.283, pp.37 - 42, 2018-10

7

Minimizing Clonal Variation during Mammalian Cell Line Engineering for Improved Systems Biology Data Generation

Grav, Lise Marie; Sergeeva, Dania; Lee, Jae Seong; de Mas, Igor Marin; Lewis, Nathan E.; Andersen, Mikael Rordam; Nielsen, Lars Keld; Lee, Gyun Minresearcher; Kildegaard, Helene FaustrupAMER CHEMICAL SOCACS SYNTHETIC BIOLOGY, v.7, no.9, pp.2148 - 2159, 2018-09

8

Untangling the mechanism of 3-methyladenine in enhancing the specific productivity: Transcriptome analysis of recombinant Chinese hamster ovary cells treated with 3-methyladenine

Baek, Eric H; Lee, Jae Seong; Lee, Gyun MinresearcherWILEYBIOTECHNOLOGY AND BIOENGINEERING, v.115, no.9, pp.2243 - 2254, 2018-09

9

Simple and Robust N-Glycan Analysis Based on Improved 2-Aminobenzoic Acid Labeling for Recombinant Therapeutic Glycoproteins

Jeong, Yeong Ran; Kim, Sun Young; Park, Young Sam; Lee, Gyun MinresearcherELSEVIER SCIENCE INCJOURNAL OF PHARMACEUTICAL SCIENCES, v.107, no.7, pp.1831 - 1841, 2018-07

10

Co-amplification of EBNA-1 and PyLT through dhfr-mediated gene amplification for improving foreign protein production in transient gene expression in CHO cells

Lee, Joohyoung; Park, Jong-Ho; Park, Sun-Hye; Kim, Sun-Hong; Kim, Jee-Yon; Min, Jeong-Ki; Lee, Gyun Minresearcher; Kim, Yeon-GuSPRINGERAPPLIED MICROBIOLOGY AND BIOTECHNOLOGY, v.102, no.11, pp.4729 - 4739, 2018-06

11

Glutamine synthetase gene knockout-human embryonic kidney 293E cells for stable production of monoclonal antibodies

Yu, Da Young; Lee, Sang Yoon; Lee, Gyun MinresearcherWILEYBIOTECHNOLOGY AND BIOENGINEERING, v.115, no.5, pp.1367 - 1372, 2018-05

12

Comprehensive Physicochemical and Biological Characterization of the Proposed Biosimilar Darbepoetin-a, LBDE and Originator Darbepoetin-a, NESP®

Jeong, Yeong Ran; Jeong, Rae Ung; Son, Jeong Hyun; Kwon, Joon Cheol; Jung, Saem; Song, Mi A; Hwang, Jin Ah; Lee, Gyun MinresearcherADIS INT LTDBIODRUGS, v.32, no.2, pp.153 - 168, 2018-04

13

Comprehensive Physicochemical and Biological Characterization of the Proposed Biosimilar Darbepoetin Alfa, LBDE, and Its Originator Darbepoetin Alfa, NESPA (R)

Jeong, Yeong Ran; Jeong, Rae Ung; Son, Jeong Hyun; Kwon, Joon Cheol; Jung, Saem; Song, Mi A.; Hwang, Jin Ah; Lee, Gyun MinresearcherADIS INT LTDBIODRUGS, v.32, no.2, pp.153 - 168, 2018-04

14

Baicalein Reduces Oxidative Stress in CHO Cell Cultures and Improves Recombinant Antibody Productivity

Ha, Tae Kwang; Hansen, Anders Holmgaard; Kol, Stefan; Kildegaard, Helene Faustrup; Lee, Gyun MinresearcherElsevierBiotechnology Journal, v.13, no.3, 2018-03

15

Using Titer and Titer Normalized to Confluence Are Complementary Strategies for Obtaining Chinese Hamster Ovary Cell Lines with High Volumetric Productivity of Etanercept

Pristovsek, Nusa; Hansen, Henning Gram; Sergeeva, Daria; Borth, Nicole; Lee, Gyun Minresearcher; Andersen, Mikael Rordam; Kildegaard, Helene FaustrupWILEY-V C H VERLAG GMBHBIOTECHNOLOGY JOURNAL, v.13, no.3, pp.1 - 10, 2018-03

16

Comprehensive characterization of glutamine synthetase-mediated selection for the establishment of recombinant CHO cells producing monoclonal antibodies

Noh, Soo Min; Shin, Seunghyeon; Lee, Gyun MinresearcherNATURE PUBLISHING GROUPSCIENTIFIC REPORTS, v.8, no.5361, pp.1 - 11, 2018-03 View PDF (2109kb)

17

Proteomic analysis of host cell protein dynamics in the supernatant of Fc-fusion protein-producing CHO DG44 and DUKX-B11 cell lines in batch and fed-batch cultures

Park, Jin-Hyoung; Jin, Jong Hwa; Ji, In Jung; An, Hyun Joo; Kim, Jong Won; Lee, Gyun MinresearcherWILEYBIOTECHNOLOGY AND BIOENGINEERING, v.114, no.10, pp.2267 - 2278, 2017-10

18

Understanding of decreased sialylation of Fc-fusion protein in hyperosmotic recombinant Chinese hamster ovary cell culture: N-glycosylation gene expression and N-linked glycan antennary profile

Lee, Jong Hyun; Jeong, Yeong Ran; Kim, Yeon-Gu; Lee, Gyun MinresearcherWILEY-BLACKWELLBIOTECHNOLOGY AND BIOENGINEERING, v.114, no.8, pp.1721 - 1732, 2017-08

19

Investigation of relationship between EBNA-1 expression level and specific foreign protein productivity in transient gene expression of HEK293 cells

Lee, Joo Hyoung; Lim, Sung-Min; Park, Sun-Hye; Min, Jeong-Ki; Lee, Gyun Minresearcher; Kim, Yeon-GuELSEVIER SCI LTDPROCESS BIOCHEMISTRY, v.55, pp.182 - 186, 2017-04

20

Proteomic Analysis of Host Cell Protein Dynamics in the Culture Supernatants of Antibody-Producing CHO Cells

Park, Jin-Hyoung; Jin, Jong Hwa; Lim, Myung Sin; An, Hyun Joo; Kim, Jong Won; Lee, Gyun MinresearcherNATURE PUBLISHING GROUPSCIENTIFIC REPORTS, v.7, no.0, pp.1 - 13, 2017-03 View PDF (2964kb)

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