Researcher Page

사진

Lee, Gyun Min (이균민) C-2020-2011

Department
Department of Biological Sciences(생명과학과)
Co-author
Collaboration Network Collaboration Network
Website
http://bs.kaist.ac.kr/~acelab/HomePage
Research Area
Proteomics, Cell engineering, Bio-reactor (Fed-batch, Perfusion culture)

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1

Proteomic analysis of host cell protein dynamics in the supernatant of Fc-fusion protein-producing CHO DG44 and DUKX-B11 cell lines in batch and fed-batch cultures

Park, Jin-Hyoung; Jin, Jong Hwa; Ji, In Jung; An, Hyun Joo; Kim, Jong Won; Lee, Gyun MinresearcherWILEYBIOTECHNOLOGY AND BIOENGINEERING, v.114, no.10, pp.2267 - 2278, 2017-10

2

Understanding of decreased sialylation of Fc-fusion protein in hyperosmotic recombinant Chinese hamster ovary cell culture: N-glycosylation gene expression and N-linked glycan antennary profile

Lee, Jong Hyun; Jeong, Yeong Ran; Kim, Yeon-Gu; Lee, Gyun MinresearcherWILEY-BLACKWELLBIOTECHNOLOGY AND BIOENGINEERING, v.114, no.8, pp.1721 - 1732, 2017-08

3

Investigation of relationship between EBNA-1 expression level and specific foreign protein productivity in transient gene expression of HEK293 cells

Lee, Joo Hyoung; Lim, Sung-Min; Park, Sun-Hye; Min, Jeong-Ki; Lee, Gyun Minresearcher; Kim, Yeon-GuELSEVIER SCI LTDPROCESS BIOCHEMISTRY, v.55, pp.182 - 186, 2017-04

4

Proteomic Analysis of Host Cell Protein Dynamics in the Culture Supernatants of Antibody-Producing CHO Cells

Park, Jin-Hyoung; Jin, Jong Hwa; Lim, Myung Sin; An, Hyun Joo; Kim, Jong Won; Lee, Gyun MinresearcherNATURE PUBLISHING GROUPSCIENTIFIC REPORTS, v.7, 2017-03 View PDF (2964kb)

5

Reduction of ammonia and lactate through the coupling of glutamine synthetase selection and downregulation of lactate dehydrogenase-A in CHO cells

Noh, Soo Min; Park, Jin-Hyoung; Lim, Myung Sin; Kim, Jong Won; Lee, Gyun MinresearcherSPRINGERAPPLIED MICROBIOLOGY AND BIOTECHNOLOGY, v.101, no.3, pp.1035 - 1045, 2017-02

6

Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions

Hansen, Henning Gram; Pristovsek, Nusa; Kildegaard, Helene Faustrup; Lee, Gyun MinresearcherPERGAMON-ELSEVIER SCIENCE LTDBIOTECHNOLOGY ADVANCES, v.35, no.1, pp.64 - 76, 2017-01

7

Ribosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion

Kallehauge, Thomas Beuchert; Li, Shangzhong; Pedersen, Lasse Ebdrup; Ha, Tae Kwang; Ley, Daniel; Andersen, Mikael Rordam; Kildegaard, Helene Faustrup; Lee, Gyun Minresearcher; Lewis, Nathan E.NATURE PUBLISHING GROUPSCIENTIFIC REPORTS, v.7, 2017-01 View PDF (11163kb)

8

Case study on human alpha 1-antitrypsin: Recombinant protein titers obtained by commercial ELISA kits are inaccurate

Hansen, Henning Gram; Kildegaard, Helene Faustrup; Lee, Gyun Minresearcher; Kol, StefanWILEY-V C H VERLAG GMBHBIOTECHNOLOGY JOURNAL, v.11, no.12, pp.1648 - 1656, 2016-12

9

Accelerated Homology-Directed Targeted Integration of Transgenes in Chinese Hamster Ovary Cells Via CRISPR/Cas9 and Fluorescent Enrichment

Lee, Jae Seong; Grav, Lise Marie; Pedersen, Lasse Ebdrup; Lee, Gyun Minresearcher; Kildegaard, Helene FaustrupWILEY-BLACKWELLBIOTECHNOLOGY AND BIOENGINEERING, v.113, no.11, pp.2518 - 2523, 2016-11

10

Targeted Gene Deletion Using DNA-Free RNA-Guided Cas9 Nuclease Accelerates Adaptation of CHO Cells to Suspension Culture

Lee, namil; Shin, Jongoh; Park, Jin-Hyoung; Lee, Gyun Minresearcher; Suhyung Cho; Cho, Byung-KwanresearcherAMER CHEMICAL SOCACS SYNTHETIC BIOLOGY, v.5, no.11, pp.1211 - 1219, 2016-11

11

Endoplasmic reticulum-directed recombinant mRNA displays subcellular localization equal to endogenous mRNA during transient expression in CHO cells

Kallehauge, Thomas Beuchert; Kol, Stefan; Andersen, Mikael Rordam; Damgaard, Christian Kroun; Lee, Gyun Minresearcher; Kildegaard, Helene FaustrupWILEY-BLACKWELLBIOTECHNOLOGY JOURNAL, v.11, no.10, pp.1362 - 1367, 2016-10

12

Chemical Inhibition of Autophagy: Examining Its Potential to Increase the Specific Productivity of Recombinant CHO Cell Lines

Baek, Eric H; Kim, Che Lin; Kim, Mi Gyeom; Lee, Jae Seong; Lee, Gyun MinresearcherWILEY-BLACKWELLBIOTECHNOLOGY AND BIOENGINEERING, v.113, no.9, pp.1953 - 1961, 2016-09

13

The molecular weight and concentration of dextran sulfate affect cell growth and antibody production in CHO cell cultures

Park, Jin-Hyoung; Lim, Myung Sin; Woo, Ju Rang; Kim, Jong Won; Lee, Gyun MinresearcherWILEY-BLACKWELLBIOTECHNOLOGY PROGRESS, v.32, no.5, pp.1113 - 1122, 2016-09

14

Combinatorial treatment with lithium chloride enhances recombinant antibody production in transiently transfected CHO and HEK293E cells

Kim, Che Lin; Ha, Tae Kwang; Lee, Gyun MinresearcherKOREAN SOC BIOTECHNOLOGY & BIOENGINEERINGBIOTECHNOLOGY AND BIOPROCESS ENGINEERING, v.21, no.5, pp.667 - 675, 2016-09

15

Limitations to the development of recombinant human embryonic kidney 293E cells using glutamine synthetase-mediated gene amplification: Methionine sulfoximine resistance

Yu, Da Young; Noh, Soo Min; Lee, Gyun MinresearcherELSEVIER SCIENCE BVJOURNAL OF BIOTECHNOLOGY, v.231, pp.136 - 140, 2016-08

16

Alleviation of proteolytic degradation of recombinant human bone morphogenetic protein-4 by repeated batch culture of Chinese hamster ovary cells

Kim, Che Lin; Bang, You Lim; Kim, Young Sik; Jang, Ju Woong; Lee, Gyun MinresearcherELSEVIER SCI LTDPROCESS BIOCHEMISTRY, v.51, no.8, pp.1078 - 1084, 2016-08

17

Heparan sulfate proteoglycan synthesis in CHO DG44 and HEK293 cells

Lee, Sojeong; Kim, Mi Gyeom; Kim, Nury; Heo, Won Doresearcher; Lee, Gyun MinresearcherKOREAN SOC BIOTECHNOLOGY & BIOENGINEERINGBIOTECHNOLOGY AND BIOPROCESS ENGINEERING, v.21, no.3, pp.439 - 445, 2016-06

18

Valeric acid induces cell cycle arrest at G1 phase in CHO cell cultures and improves recombinant antibody productivity

Park, Jin-Hyoung; Noh, Soo Min; Woo, Ju Rang; Kim, Jong Won; Lee, Gyun MinresearcherWILEY-BLACKWELLBIOTECHNOLOGY JOURNAL, v.11, no.4, pp.487 - 496, 2016-04

19

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Klionsky, Daniel J.; Abdelmohsen, Kotb; Abe, Akihisa; Abedin, Md Joynal; Lee, Gyun MinresearcherTAYLOR FRANCIS INCAUTOPHAGY, v.12, no.1, pp.1 - 222, 2016

20

Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells

Hansen, Henning Gram; Nilsson, Claes Nymand; Lund, Anne Mathilde; Kol, Stefan; Grav, Lise Marie; Lundqvist, Magnus; Rockberg, Johan; Lee, Gyun Minresearcher; Andersen, Mikael Rordam; Kildegaard, Helene FaustrupNATURE PUBLISHING GROUPSCIENTIFIC REPORTS, v.5, 2015-12

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