Researcher Page

사진

Lee, Gyun Min (이균민) C-2020-2011

Department
Department of Biological Sciences(생명과학과)
Co-author
Collaboration Network Collaboration Network
Website
http://bs.kaist.ac.kr/~acelab/HomePage
Research Area
Proteomics, Cell engineering, Bio-reactor (Fed-batch, Perfusion culture)

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1

Co-amplification of EBNA-1 and PyLT through dhfr-mediated gene amplification for improving foreign protein production in transient gene expression in CHO cells

Lee, Joohyoung; Park, Jong-Ho; Park, Sun-Hye; Kim, Sun-Hong; Kim, Jee-Yon; Min, Jeong-Ki; Lee, Gyun Minresearcher; Kim, Yeon-GuSPRINGERAPPLIED MICROBIOLOGY AND BIOTECHNOLOGY, v.102, no.11, pp.4729 - 4739, 2018-06

2

Glutamine synthetase gene knockout-human embryonic kidney 293E cells for stable production of monoclonal antibodies

Yu, Da Young; Lee, Sang Yoon; Lee, Gyun MinresearcherWILEYBIOTECHNOLOGY AND BIOENGINEERING, v.115, no.5, pp.1367 - 1372, 2018-05

3

Comprehensive Physicochemical and Biological Characterization of the Proposed Biosimilar Darbepoetin Alfa, LBDE, and Its Originator Darbepoetin Alfa, NESPA (R)

Jeong, Yeong Ran; Jeong, Rae Ung; Son, Jeong Hyun; Kwon, Joon Cheol; Jung, Saem; Song, Mi A.; Hwang, Jin Ah; Lee, Gyun MinresearcherADIS INT LTDBIODRUGS, v.32, no.2, pp.153 - 168, 2018-04

4

Comprehensive characterization of glutamine synthetase-mediated selection for the establishment of recombinant CHO cells producing monoclonal antibodies

Noh, Soo Min; Shin, Seunghyeon; Lee, Gyun MinresearcherNATURE PUBLISHING GROUPSCIENTIFIC REPORTS, v.8, no.5361, pp.1 - 11, 2018-03

5

Using Titer and Titer Normalized to Confluence Are Complementary Strategies for Obtaining Chinese Hamster Ovary Cell Lines with High Volumetric Productivity of Etanercept

Pristovsek, Nusa; Hansen, Henning Gram; Sergeeva, Daria; Borth, Nicole; Lee, Gyun Minresearcher; Andersen, Mikael Rordam; Kildegaard, Helene FaustrupWILEY-V C H VERLAG GMBHBIOTECHNOLOGY JOURNAL, v.13, no.3, pp.1 - 10, 2018-03

6

Baicalein Reduces Oxidative Stress in CHO Cell Cultures and Improves Recombinant Antibody Productivity

Ha, Tae Kwang; Hansen, Anders Holmgaard; Kol, Stefan; Kildegaard, Helene Faustrup; Lee, Gyun MinresearcherElsevierBiotechnology Journal, v.13, no.3, 2018-03

7

Proteomic analysis of host cell protein dynamics in the supernatant of Fc-fusion protein-producing CHO DG44 and DUKX-B11 cell lines in batch and fed-batch cultures

Park, Jin-Hyoung; Jin, Jong Hwa; Ji, In Jung; An, Hyun Joo; Kim, Jong Won; Lee, Gyun MinresearcherWILEYBIOTECHNOLOGY AND BIOENGINEERING, v.114, no.10, pp.2267 - 2278, 2017-10

8

Understanding of decreased sialylation of Fc-fusion protein in hyperosmotic recombinant Chinese hamster ovary cell culture: N-glycosylation gene expression and N-linked glycan antennary profile

Lee, Jong Hyun; Jeong, Yeong Ran; Kim, Yeon-Gu; Lee, Gyun MinresearcherWILEY-BLACKWELLBIOTECHNOLOGY AND BIOENGINEERING, v.114, no.8, pp.1721 - 1732, 2017-08

9

Investigation of relationship between EBNA-1 expression level and specific foreign protein productivity in transient gene expression of HEK293 cells

Lee, Joo Hyoung; Lim, Sung-Min; Park, Sun-Hye; Min, Jeong-Ki; Lee, Gyun Minresearcher; Kim, Yeon-GuELSEVIER SCI LTDPROCESS BIOCHEMISTRY, v.55, pp.182 - 186, 2017-04

10

Proteomic Analysis of Host Cell Protein Dynamics in the Culture Supernatants of Antibody-Producing CHO Cells

Park, Jin-Hyoung; Jin, Jong Hwa; Lim, Myung Sin; An, Hyun Joo; Kim, Jong Won; Lee, Gyun MinresearcherNATURE PUBLISHING GROUPSCIENTIFIC REPORTS, v.7, no.0, pp.1 - 13, 2017-03 View PDF (2964kb)

11

Reduction of ammonia and lactate through the coupling of glutamine synthetase selection and downregulation of lactate dehydrogenase-A in CHO cells

Noh, Soo Min; Park, Jin-Hyoung; Lim, Myung Sin; Kim, Jong Won; Lee, Gyun MinresearcherSPRINGERAPPLIED MICROBIOLOGY AND BIOTECHNOLOGY, v.101, no.3, pp.1035 - 1045, 2017-02

12

Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions

Hansen, Henning Gram; Pristovsek, Nusa; Kildegaard, Helene Faustrup; Lee, Gyun MinresearcherPERGAMON-ELSEVIER SCIENCE LTDBIOTECHNOLOGY ADVANCES, v.35, no.1, pp.64 - 76, 2017-01

13

Ribosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion

Kallehauge, Thomas Beuchert; Li, Shangzhong; Pedersen, Lasse Ebdrup; Ha, Tae Kwang; Ley, Daniel; Andersen, Mikael Rordam; Kildegaard, Helene Faustrup; Lee, Gyun Minresearcher; Lewis, Nathan E.NATURE PUBLISHING GROUPSCIENTIFIC REPORTS, v.7, pp.1 - 10, 2017-01 View PDF (11163kb)

14

Case study on human alpha 1-antitrypsin: Recombinant protein titers obtained by commercial ELISA kits are inaccurate

Hansen, Henning Gram; Kildegaard, Helene Faustrup; Lee, Gyun Minresearcher; Kol, StefanWILEY-V C H VERLAG GMBHBIOTECHNOLOGY JOURNAL, v.11, no.12, pp.1648 - 1656, 2016-12

15

Targeted Gene Deletion Using DNA-Free RNA-Guided Cas9 Nuclease Accelerates Adaptation of CHO Cells to Suspension Culture

Lee, namil; Shin, Jongoh; Park, Jin-Hyoung; Lee, Gyun Minresearcher; Suhyung Cho; Cho, Byung-KwanresearcherAMER CHEMICAL SOCACS SYNTHETIC BIOLOGY, v.5, no.11, pp.1211 - 1219, 2016-11

16

Accelerated Homology-Directed Targeted Integration of Transgenes in Chinese Hamster Ovary Cells Via CRISPR/Cas9 and Fluorescent Enrichment

Lee, Jae Seong; Grav, Lise Marie; Pedersen, Lasse Ebdrup; Lee, Gyun Minresearcher; Kildegaard, Helene FaustrupWILEY-BLACKWELLBIOTECHNOLOGY AND BIOENGINEERING, v.113, no.11, pp.2518 - 2523, 2016-11

17

Endoplasmic reticulum-directed recombinant mRNA displays subcellular localization equal to endogenous mRNA during transient expression in CHO cells

Kallehauge, Thomas Beuchert; Kol, Stefan; Andersen, Mikael Rordam; Damgaard, Christian Kroun; Lee, Gyun Minresearcher; Kildegaard, Helene FaustrupWILEY-BLACKWELLBIOTECHNOLOGY JOURNAL, v.11, no.10, pp.1362 - 1367, 2016-10

18

The molecular weight and concentration of dextran sulfate affect cell growth and antibody production in CHO cell cultures

Park, Jin-Hyoung; Lim, Myung Sin; Woo, Ju Rang; Kim, Jong Won; Lee, Gyun MinresearcherWILEY-BLACKWELLBIOTECHNOLOGY PROGRESS, v.32, no.5, pp.1113 - 1122, 2016-09

19

Combinatorial treatment with lithium chloride enhances recombinant antibody production in transiently transfected CHO and HEK293E cells

Kim, Che Lin; Ha, Tae Kwang; Lee, Gyun MinresearcherKOREAN SOC BIOTECHNOLOGY & BIOENGINEERINGBIOTECHNOLOGY AND BIOPROCESS ENGINEERING, v.21, no.5, pp.667 - 675, 2016-09

20

Chemical Inhibition of Autophagy: Examining Its Potential to Increase the Specific Productivity of Recombinant CHO Cell Lines

Baek, Eric H; Kim, Che Lin; Kim, Mi Gyeom; Lee, Jae Seong; Lee, Gyun MinresearcherWILEY-BLACKWELLBIOTECHNOLOGY AND BIOENGINEERING, v.113, no.9, pp.1953 - 1961, 2016-09

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