Researcher Page

사진

Lee, Gyun Min (이균민) C-2020-2011

Department
Department of Biological Sciences(생명과학과)
Co-author
Collaboration Network Collaboration Network
Website
http://bs.kaist.ac.kr/~acelab/HomePage
Research Area
Proteomics, Cell engineering, Bio-reactor (Fed-batch, Perfusion culture)

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1

Reduction of ammonia and lactate through the coupling of glutamine synthetase selection and downregulation of lactate dehydrogenase-A in CHO cells

Noh, Soo Min; Park, Jin-Hyoung; Lim, Myung Sin; Kim, Jong Won; Lee, Gyun MinresearcherSPRINGERAPPLIED MICROBIOLOGY AND BIOTECHNOLOGY, v.101, no.3, pp.1035 - 1045, 2017-02

2

Improving the secretory capacity of Chinese hamster ovary cells by ectopic expression of effector genes: Lessons learned and future directions

Hansen, Henning Gram; Pristovsek, Nusa; Kildegaard, Helene Faustrup; Lee, Gyun MinresearcherPERGAMON-ELSEVIER SCIENCE LTDBIOTECHNOLOGY ADVANCES, v.35, no.1, pp.64 - 76, 2017-01

3

Ribosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion

Kallehauge, Thomas Beuchert; Li, Shangzhong; Pedersen, Lasse Ebdrup; Ha, Tae Kwang; Ley, Daniel; Andersen, Mikael Rordam; Kildegaard, Helene Faustrup; Lee, Gyun Minresearcher; Lewis, Nathan E.NATURE PUBLISHING GROUPSCIENTIFIC REPORTS, v.7, 2017-01

4

Case study on human alpha 1-antitrypsin: Recombinant protein titers obtained by commercial ELISA kits are inaccurate

Hansen, Henning Gram; Kildegaard, Helene Faustrup; Lee, Gyun Minresearcher; Kol, StefanWILEY-V C H VERLAG GMBHBIOTECHNOLOGY JOURNAL, v.11, no.12, pp.1648 - 1656, 2016-12

5

Targeted Gene Deletion Using DNA-Free RNA-Guided Cas9 Nuclease Accelerates Adaptation of CHO Cells to Suspension Culture

Lee, namil; Shin, Jongoh; Park, Jin-Hyoung; Lee, Gyun Minresearcher; Suhyung Cho; Cho, Byung-KwanresearcherAMER CHEMICAL SOCACS SYNTHETIC BIOLOGY, v.5, no.11, pp.1211 - 1219, 2016-11

6

Endoplasmic reticulum-directed recombinant mRNA displays subcellular localization equal to endogenous mRNA during transient expression in CHO cells

Kallehauge, Thomas Beuchert; Kol, Stefan; Andersen, Mikael Rordam; Damgaard, Christian Kroun; Lee, Gyun Minresearcher; Kildegaard, Helene FaustrupWILEY-BLACKWELLBIOTECHNOLOGY JOURNAL, v.11, no.10, pp.1362 - 1367, 2016-10

7

Combinatorial treatment with lithium chloride enhances recombinant antibody production in transiently transfected CHO and HEK293E cells

Kim, Che Lin; Ha, Tae Kwang; Lee, Gyun MinresearcherKOREAN SOC BIOTECHNOLOGY & BIOENGINEERINGBIOTECHNOLOGY AND BIOPROCESS ENGINEERING, v.21, no.5, pp.667 - 675, 2016-09

8

The molecular weight and concentration of dextran sulfate affect cell growth and antibody production in CHO cell cultures

Park, Jin-Hyoung; Lim, Myung Sin; Woo, Ju Rang; Kim, Jong Won; Lee, Gyun MinresearcherWILEY-BLACKWELLBIOTECHNOLOGY PROGRESS, v.32, no.5, pp.1113 - 1122, 2016-09

9

Valeric acid induces cell cycle arrest at G1 phase in CHO cell cultures and improves recombinant antibody productivity

Park, Jin-Hyoung; Noh, Soo Min; Woo, Ju Rang; Kim, Jong Won; Lee, Gyun MinresearcherWILEY-BLACKWELLBIOTECHNOLOGY JOURNAL, v.11, no.4, pp.487 - 496, 2016-04

10

Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells

Hansen, Henning Gram; Nilsson, Claes Nymand; Lund, Anne Mathilde; Kol, Stefan; Grav, Lise Marie; Lundqvist, Magnus; Rockberg, Johan; Lee, Gyun Minresearcher; Andersen, Mikael Rordam; Kildegaard, Helene FaustrupNATURE PUBLISHING GROUPSCIENTIFIC REPORTS, v.5, 2016-01

11

One-step generation of triple knockout CHO cell lines using CRISPR/Cas9 and fluorescent enrichment

Grav, Lise Marie; Lee, Jae Seong; Gerling, Signe; Kallehauge, Thomas Beuchert; Hansen, Anders Holmgaard; Kol, Stefan; Lee, Gyun Minresearcher; Pedersen, Lasse Ebdrup; Kildegaard, Helene FaustrupWILEY-V C H VERLAG GMBHBIOTECHNOLOGY JOURNAL, v.10, no.9, pp.1446 - 1456, 2015-09

12

Efficient CRISPR/Cas9-mediated multiplex genome editing in CHO cells via high-level sgRNA-Cas9 complex

Shin, Jongoh; Lee, Namil; Song, Yoseb; Park, Jinhyung; Kang, Taek Jin; Kim, Sun Changresearcher; Lee, Gyun Minresearcher; Cho, Byung-KwanresearcherKOREAN SOC BIOTECHNOLOGY BIOENGINEERINGBIOTECHNOLOGY AND BIOPROCESS ENGINEERING, v.20, no.5, pp.825 - 833, 2015-09

13

Purification of TNFR-Fc produced in recombinant CHO cells: Characterization of product-related impurities

Min, Kyunghyun; Lee, Gyun MinresearcherELSEVIER SCI LTDPROCESS BIOCHEMISTRY, v.50, no.8, pp.1313 - 1317, 2015-08

14

Understanding of altered N-glycosylation-related gene expression in recombinant Chinese hamster ovary cells subjected to elevated ammonium concentration by digital mRNA counting

Ha, Tae-Kwang; Kim, Yeon-Gu; Lee, Gyun-MinresearcherWILEY-BLACKWELLBIOTECHNOLOGY AND BIOENGINEERING, v.112, no.8, pp.1583 - 1593, 2015-08

15

Effect of Bcl-x(L) overexpression on sialylation of Fc-fusion protein in recombinant Chinese hamster ovary cell cultures

Lee, Jong Hyun; Kim, Yeon-Gu; Lee, Gyun MinresearcherWILEY-BLACKWELLBIOTECHNOLOGY PROGRESS, v.31, no.4, pp.1133 - 1137, 2015-07

16

Characterization and Expression of Proprotein Convertases in CHO Cells: Efficient Proteolytic Maturation of Human Bone Morphogenetic Protein-7

Sathya Murthy, Madhavi; Kim, Che Lin; Bang, You Lim; Kim, Young Sik; Jang, Ju Woong; Lee, Gyun-MinresearcherWILEY-BLACKWELLBIOTECHNOLOGY AND BIOENGINEERING, v.112, no.3, pp.560 - 568, 2015-03

17

Novel Glycosylated VEGF Decoy Receptor Fusion Protein, VEGF-Grab, Efficiently Suppresses Tumor Angiogenesis and Progression

Lee, Jung-Eun; Kim, Chan; Yang, Hannah; Park, Intae; Oh, Nuri; Hua, Serenus; Jeong, Haneul; An, Hyun Joo; Kim, Sun Changresearcher; Lee, Gyun Minresearcher; Koh, Gou Youngresearcher; Kim, Ho-MinresearcherAMER ASSOC CANCER RESEARCHMOLECULAR CANCER THERAPEUTICS, v.14, no.2, pp.470 - 479, 2015-02

18

Electrospun chitosan/poly(vinyl alcohol) reinforced with CaCO3 nanoparticles with enhanced mechanical properties and biocompatibility for cartilage tissue engineering

Sambudi, Nonni Soraya; Sathya Murthy, Madhavi; Lee, Gyun-Minresearcher; Park, Seung-BinresearcherELSEVIER SCI LTDCOMPOSITES SCIENCE AND TECHNOLOGY, v.106, pp.76 - 84, 2015-01

19

Effect of lithium chloride on the production and sialylation of Fc-fusion protein in Chinese hamster ovary cell culture

Ha, Taekwang; Kim, Yeon-Gu; Lee, Gyun-MinresearcherSPRINGERAPPLIED MICROBIOLOGY AND BIOTECHNOLOGY, v.98, no.22, pp.9239 - 9248, 2014-11

20

Effect of glutamine substitution by TCA cycle intermediates on the production and sialylation of Fc-fusion protein in Chinese hamster ovary cell culture

Ha, Tae Kwang; Lee, Gyun MinresearcherELSEVIER SCIENCE BVJOURNAL OF BIOTECHNOLOGY, v.180, pp.23 - 29, 2014-06

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