Theoretical Estimation of Cannulation Methods for Left Ventricular Assist Device Support as a Bridge to Recovery

Cited 6 time in webofscience Cited 0 time in scopus
  • Hit : 188
  • Download : 68
Left ventricular assist device (LVAD) support under cannulation connected from the left atrium to the aorta (LA-AA) is used as a bridge to recovery in heart failure patients because it is non-invasive to ventricular muscle. However, it has serious problems, such as valve stenosis and blood thrombosis due to the low ejection fraction of the ventricle. We theoretically estimated the effect of the in-series cannulation, connected from ascending aorta to descending aorta (AA-DA), on ventricular unloading as an alternative to the LA-AA method. We developed a theoretical model of a LVAD-implanted cardiovascular system that included coronary circulation. Using this model, we compared hemodynamic responses according to various cannulation methods such as LA-AA, AA-DA, and a cannulation connected from the left ventricle to ascending aorta (LV-AA), under continuous and pulsatile LVAD supports. The AA-DA method provided 14% and 18% less left ventricular peak pressure than the LA-AA method under continuous and pulsatile LVAD conditions, respectively. The LA-AA method demonstrated higher coronary flow than AADA method. Therefore, the LA-AA method is more advantageous in increasing ventricular unloading whereas the AA-DA method is a better choice to increase coronary perfusion.
Publisher
KOREAN ACAD MEDICAL SCIENCES
Issue Date
2011-12
Language
English
Article Type
Article
Keywords

CONGESTIVE-HEART-FAILURE; FAILING LEFT-VENTRICLE; HEMODYNAMICS; MODEL; FLOW; CIRCULATION; DOBUTAMINE; SIMULATION; MILRINONE; DYNAMICS

Citation

JOURNAL OF KOREAN MEDICAL SCIENCE, v.26, no.12, pp.1591 - 1598

ISSN
1011-8934
URI
http://hdl.handle.net/10203/99500
Appears in Collection
EE-Journal Papers(저널논문)
Files in This Item
000298034000009.pdf(700.37 kB)Download
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 6 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0