Bioinspired Synthesis and Characterization of Gadolinium-Labeled Magnetite Nanoparticles for Dual Contrast T-1- and T-2-Weighted Magnetic Resonance Imaging

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Gadolinium-labeled magnetite nanoparticles (GMNPs) were synthesized via a bioinspired manner 10 use as dual contrast agents for T-1- and T-2-weighted magnetic resonance imaging. A mussel-derived adhesive moiety, 3,4-dihydroxy-L-phenylalanine (DOPA), was utilized as a robust anchor to form a mixed layer of poly(ethylene glycol) (PEG) chains and dopamine molecules on the surface of iron oxide nanoparticlcs. Gadolinium ions were subsequently complexed at the distal end of the dopamine molecules that were prefunctionalized with a chelating ligand for gadolinium. The resultant GMNPs exhibited high dispersion stability in aqueous Solution. Crystal structure and superparamagnetic properties of magnetite nanocrystals were also maintained after the complexation of g a pits for T-1 and T-2-weighted magnetic resonance imaging was demonstrated by conducting in vitro and in vivo imaging and relaxivity measurements.
Publisher
AMER CHEMICAL SOC
Issue Date
2010-03
Language
English
Article Type
Article
Keywords

IRON-OXIDE NANOPARTICLES; FE3O4 NANOPARTICLES; CELLULAR UPTAKE; DRUG-DELIVERY; MUSSEL BYSSUS; CANCER; AGENTS; NANOCRYSTALS; FABRICATION; DESIGN

Citation

BIOCONJUGATE CHEMISTRY, v.21, pp.505 - 512

ISSN
1043-1802
DOI
10.1021/bc900424u
URI
http://hdl.handle.net/10203/99469
Appears in Collection
EE-Journal Papers(저널논문)BS-Journal Papers(저널논문)
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