Brain activation related to affective dimension during thermal stimulation in humans: A functional magnetic resonance imaging study

The aim of this study was to identify the activated brain region that is involved with the affective dimension of thermal stimulation (not pain, but innocuous warming) using functional MR imaging. Twelve healthy, right-handed male subjects participated in the study. Thermal stimulation with two different temperatures of 41 degrees C and 34 degrees C was applied to the subjects using a fomentation pack, wrapped around the right lower leg of each subject. On the basis of the subjects' responses after the scanning sessions, the authors were able to observe that the subjects felt "warm" and "slightly pleasant and comfortable" under the 41 degrees C condition. The experimental results indicated that warm stimulation produced a significant increase of activation compared to thermal neutral stimulation in various regions such as contralateral insular, ipsilateral cerebellum, ipsilateral putamen, contralateral middle frontal gyrus, ipsilateral inferior frontal gyrus, contralateral postcentral gyrus, and contralateral paracentral lobule. The activated regions are known to be related to thermal sensory, affective/emotional awareness, cognitive functions, sensory-discrimination, and emotion/affective processing, and so on. These results suggest that an appropriate thermal stimulation can produce a positive emotion and activate emotion/affect related regions of the brain.
Publisher
TAYLOR & FRANCIS LTD
Issue Date
2007-07
Language
ENG
Keywords

WORKING-MEMORY; PAIN PERCEPTION; INSULAR CORTEX; NOXIOUS HEAT; EMOTION; FMRI; PET; ATTENTION; COLD; TASK

Citation

INTERNATIONAL JOURNAL OF NEUROSCIENCE, v.117, pp.1011 - 1027

ISSN
0020-7454
DOI
10.1080/00207450600934432
URI
http://hdl.handle.net/10203/9892
Appears in Collection
EE-Journal Papers(저널논문)
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