A Surface-Charge Study on Cellular-Uptake Behavior of F3-Peptide-Conjugated Iron Oxide Nanoparticles

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Surface-charge measurements of mammalian cells in terms of Zeta potential are demonstrated as a useful biological characteristic in identifying cellular interactions with specific nanomaterials. A theoretical model of the changes in Zeta potential of cells after incubation with nanoparticles is established to predict the possible patterns of Zeta-potential change to reveal the binding and internalization effects. The experimental results show a distinct Pattern of Zeta potential change that allows the discrimination of human normal breast epithelial cells (MCF-10A) from human cancer breast epithelial cells (MCF-7) when the cells are incubated with dextran coated iron oxide nanoparticles that contain tumor-homing F3 peptides, where the tumor-homing F3 peptide specifically bound to nucleolin receptors that are overexpressed in cancer breast cells.
Publisher
WILEY-V C H VERLAG GMBH
Issue Date
2009-09
Language
English
Article Type
Article
Keywords

MRI CONTRAST AGENTS; IN-VIVO; SUPERPARAMAGNETIC NANOPARTICLES; MAGNETIC-RESONANCE; ENDOTHELIAL-CELLS; EPITHELIAL-CELLS; HOMING PEPTIDES; MESSENGER-RNA; CANCER-CELLS; NUCLEOLIN

Citation

SMALL, v.5, no.17, pp.1990 - 1996

ISSN
1613-6810
DOI
10.1002/smll.200900520
URI
http://hdl.handle.net/10203/98640
Appears in Collection
BiS-Journal Papers(저널논문)
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