Bilateral brain regions associated with naming in older adults

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To determine structural brain correlates of naming abilities in older adults, we tested 24 individuals aged 56-79 on two confrontation-naming tests (the Boston Naming Test (BNT) and the Action Naming Test (ANT)), then collected from these individuals structural Magnetic-Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI) data. Overall, several regions showed that greater gray and white matter volume/ integrity measures were associated with better task performance. Left peri-Sylvian language regions and their right-hemisphere counterparts, plus left mid-frontal gyrus correlated with accuracy and/or negatively with response time (RT) on the naming tests. Fractional anisotropy maps derived from DTI showed robust positive correlations with ANT accuracy bilaterally in the temporal lobe and in right middle frontal lobe, as well as negative correlations with BNT RT, bilaterally, in the white matter within middle and inferior temporal lobes. We conclude that those older adults with relatively better naming skills can rely on right-hemisphere peri-Sylvian and mid-frontal regions and pathways, in conjunction with left-hemisphere peri-Sylvian and mid-frontal regions, to achieve their success. Published by Elsevier Inc.
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Issue Date
2010-06
Language
English
Article Type
Article
Keywords

HUMAN CEREBRAL-CORTEX; TRANSCRANIAL MAGNETIC STIMULATION; VOXEL-BASED MORPHOMETRY; SURFACE-BASED ANALYSIS; LEFT FRONTAL-CORTEX; SHORT-TERM-MEMORY; VERBAL FLUENCY; WHITE-MATTER; BROCAS AREA; LIFE-SPAN

Citation

BRAIN AND LANGUAGE, v.113, pp.113 - 123

ISSN
0093-934X
DOI
10.1016/j.band1.2010.03.001
URI
http://hdl.handle.net/10203/98382
Appears in Collection
EE-Journal Papers(저널논문)
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