Atlas-based multichannel monitoring of functional MRI signals in real-time: Automated approach

We report an automated method to simultaneously monitor blood-oxygenation-level-dependent (BOLD) MR signals from multiple cortical areas in real-time. Individual brain anatomy was normalized and registered to a pre-segmented atlas in standardized anatomical space. Subsequently, using real-time fMRI (rtfMRI) data acquisition, localized BOLD signals were measured and displayed from user-selected areas labeled with anatomical and Brodmann's Area (BA) nomenclature. The method was tested on healthy volunteers during the performance of hand motor and internal speech generation tasks employing a trial-based design. Our data normalization and registration algorithm, along with image reconstruction, movement correction and a data display routine were executed with enough processing and communication bandwidth necessary for real-time operation. Task-specific BOLD signals were observed from the hand motor and language areas. One of the study participants was allowed to freely engage in hand clenching tasks, and associated brain activities were detected from the motor-related neural substrates without prior knowledge of the task onset time. The proposed method may be applied to various applications such as neurofeedback, brain-computer-interface, and functional mapping for surgical planning where real-time monitoring of region-specific brain activity is needed. (c) 2007 Wiley-Liss, Inc.
Publisher
WILEY-LISS
Issue Date
2008-02
Language
ENG
Keywords

NATURAL VIEWING CONDITIONS; IMAGE-GUIDED NEUROSURGERY; PRIMARY MOTOR CORTEX; BRAIN-TUMORS; FMRI; ACTIVATION; LOCALIZATION; REGISTRATION; LANGUAGE; VALIDATION

Citation

HUMAN BRAIN MAPPING, v.29, no.2, pp.157 - 166

ISSN
1065-9471
DOI
10.1002/hbm.20377
URI
http://hdl.handle.net/10203/9832
Appears in Collection
EE-Journal Papers(저널논문)
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