DC Field | Value | Language |
---|---|---|
dc.contributor.author | Fan, Zhigang | ko |
dc.contributor.author | Spencer, Joel A. | ko |
dc.contributor.author | Lu, Yan | ko |
dc.contributor.author | Pitsillides, Costas M. | ko |
dc.contributor.author | Singh, Gurbakhshish | ko |
dc.contributor.author | Kim, Pilhan | ko |
dc.contributor.author | Yun, Seok Hyun | ko |
dc.contributor.author | Toxavidis, Vasilis | ko |
dc.contributor.author | Strom, Terry B. | ko |
dc.contributor.author | Lin, Charles P. | ko |
dc.contributor.author | Koulmanda, Maria | ko |
dc.date.accessioned | 2013-03-09T14:24:30Z | - |
dc.date.available | 2013-03-09T14:24:30Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2010-06 | - |
dc.identifier.citation | NATURE MEDICINE, v.16, no.6, pp.718 - 722 | - |
dc.identifier.issn | 1078-8956 | - |
dc.identifier.uri | http://hdl.handle.net/10203/96594 | - |
dc.description.abstract | Here we present methods to longitudinally track islet allograft-infiltrating T cells in live mice by endoscopic confocal microscopy and to analyze circulating T cells by in vivo flow cytometry. We developed a new reporter mouse whose T cell subsets express distinct, 'color-coded' proteins enabling in vivo detection and identification of effector T cells (T(eff) cells) and discrimination between natural and induced regulatory T cells (nT(reg) and iT(reg) cells). Using these tools, we observed marked differences in the T cell response in recipients receiving tolerance-inducing therapy (CD154-specific monoclonal antibody plus rapamycin) compared to untreated controls. These results establish real-time cell tracking as a powerful means to probe the dynamic cellular interplay mediating immunologic rejection or transplant tolerance. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | In vivo tracking of color-coded effector, natural and induced regulatory T cells in the allograft response | - |
dc.type | Article | - |
dc.identifier.wosid | 000278394200040 | - |
dc.identifier.scopusid | 2-s2.0-77953232399 | - |
dc.type.rims | ART | - |
dc.citation.volume | 16 | - |
dc.citation.issue | 6 | - |
dc.citation.beginningpage | 718 | - |
dc.citation.endingpage | 722 | - |
dc.citation.publicationname | NATURE MEDICINE | - |
dc.identifier.doi | 10.1038/nm.2155 | - |
dc.contributor.localauthor | Kim, Pilhan | - |
dc.contributor.nonIdAuthor | Fan, Zhigang | - |
dc.contributor.nonIdAuthor | Spencer, Joel A. | - |
dc.contributor.nonIdAuthor | Lu, Yan | - |
dc.contributor.nonIdAuthor | Pitsillides, Costas M. | - |
dc.contributor.nonIdAuthor | Singh, Gurbakhshish | - |
dc.contributor.nonIdAuthor | Toxavidis, Vasilis | - |
dc.contributor.nonIdAuthor | Strom, Terry B. | - |
dc.contributor.nonIdAuthor | Lin, Charles P. | - |
dc.contributor.nonIdAuthor | Koulmanda, Maria | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | TRANSPLANTATION TOLERANCE | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | REJECTION | - |
dc.subject.keywordPlus | GENERATION | - |
dc.subject.keywordPlus | AUTOIMMUNE | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | BALANCE | - |
dc.subject.keywordPlus | FOXP3 | - |
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