Structural Biology of the Toll-Like Receptor Family

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Innate immune receptors respond to common structural patterns in microbial molecules and are called pattern recognition receptors. Toll-like receptors (TLRs) play critical roles in the innate immune system by recognizing microbial lipids, carbohydrates, nucleic acids, and proteins. Precise definition of the ligand "pattern" of TLRs has been difficult to determine primarily owing to a lack of high-resolution structures. Recently, the structures of several TLR-ligand complexes and the intracellular signaling domains have been determined by X-ray crystallography. This new structural information, combined with extensive biochemical and immunological data accumulated over decades, sheds new light on ligand-recognition and -activation mechanisms. In this review, we summarize the TLR structures and discuss proposed ligand-recognition and -activation mechanisms.
Publisher
ANNUAL REVIEWS
Issue Date
2011-06
Language
English
Article Type
Review; Book Chapter
Citation

ANNUAL REVIEW OF BIOCHEMISTRY, v.80, pp.917 - 941

ISSN
0066-4154
DOI
10.1146/annurev-biochem-052909-141507
URI
http://hdl.handle.net/10203/96228
Appears in Collection
CH-Journal Papers(저널논문)
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