We show combinatorially that the higher-order matching polynomials of several families of graphs are d-orthogonal polynomials. The matching polynomial of a graph is a generating function for coverings of a graph by disjoint edges; the higher-order matching polynomial corresponds to coverings by paths. Several families of classical orthogonal polynomials-the Chebyshev, Hermite, and Laguerre polynomials can be interpreted as matching polynomials of paths, cycles, complete graphs, and complete bipartite graphs. The notion of d-orthogonality is a generalization of the usual idea of orthogonality for polynomials and we use sign-reversing involutions to show that the higher-order Chebyshev (first and second kinds), Hermite, and Laguerre polynomials are d-orthogonal. We also investigate the moments and find generating functions of those polynomials. (C) 2010 Elsevier Inc. All rights reserved.