Antifibrotic Effect of MMP13-encoding Plasmid DNA Delivered Using Polyethylenimine Shielded With Hyaluronic Acid

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dc.contributor.authorKim, Eun-Joongko
dc.contributor.authorCho, Hee-Jeongko
dc.contributor.authorPark, Daeuiko
dc.contributor.authorKim, Ji Yeonko
dc.contributor.authorKim, Young Bongko
dc.contributor.authorPark, Tae Gwanko
dc.contributor.authorShim, Chang-Kooko
dc.contributor.authorOh, Yu-Kyoungko
dc.date.accessioned2013-03-08T19:45:19Z-
dc.date.available2013-03-08T19:45:19Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2011-02-
dc.identifier.citationMOLECULAR THERAPY, v.19, no.2, pp.355 - 361-
dc.identifier.issn1525-0016-
dc.identifier.urihttp://hdl.handle.net/10203/94087-
dc.description.abstractThe imbalanced expression of matrix metalloproteinases (MMPs) is associated with liver fibrosis, one of the most common chronic liver diseases. Enhanced expression of MMPs by gene therapy is emerging as a promising antifibrotic strategy, but the effectiveness of this approach depends on reliable systems for delivering MMP genes. Here, we evaluated a newly designed hyaluronic acid (HA)-shielded delivery system for systemic administration of plasmid DNA encoding MMP13 (pMMP13), and tested whether the enhanced expression of MMP13 ameliorates liver fibrosis in mice. In the CCl(4)-induced liver fibrosis model, systemic administration of pMMP13 using HA and polyethylenimine (PEI) significantly increased the expression of MMP13 and reduced collagen deposition. Moreover, following delivery of pMMP13 in a HA-shielded PEI complex, the serum levels of aspartate transaminase were reduced to levels approaching those in untreated normal mice. These results indicate that the delivery of pMMP13 using HA-shielded PEI enhances the efficiency of MMP13 expression in the liver, and highlight the potential of pMMP13 gene therapy as an antifibrotic strategy.-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.subjectLIVER FIBROSIS-
dc.subjectGENE DELIVERY-
dc.subjectRAT-LIVER-
dc.subjectRECEPTOR-
dc.subjectENDOCYTOSIS-
dc.subjectEXPRESSION-
dc.subjectCYTOTOXICITY-
dc.subjectSTRATEGIES-
dc.subjectTHERAPIES-
dc.subjectCOMPLEXES-
dc.titleAntifibrotic Effect of MMP13-encoding Plasmid DNA Delivered Using Polyethylenimine Shielded With Hyaluronic Acid-
dc.typeArticle-
dc.identifier.wosid000286923000020-
dc.identifier.scopusid2-s2.0-79551615156-
dc.type.rimsART-
dc.citation.volume19-
dc.citation.issue2-
dc.citation.beginningpage355-
dc.citation.endingpage361-
dc.citation.publicationnameMOLECULAR THERAPY-
dc.identifier.doi10.1038/mt.2010.262-
dc.contributor.localauthorPark, Tae Gwan-
dc.contributor.nonIdAuthorKim, Eun-Joong-
dc.contributor.nonIdAuthorCho, Hee-Jeong-
dc.contributor.nonIdAuthorPark, Daeui-
dc.contributor.nonIdAuthorKim, Ji Yeon-
dc.contributor.nonIdAuthorKim, Young Bong-
dc.contributor.nonIdAuthorShim, Chang-Koo-
dc.contributor.nonIdAuthorOh, Yu-Kyoung-
dc.type.journalArticleArticle-
dc.subject.keywordPlusLIVER FIBROSIS-
dc.subject.keywordPlusGENE DELIVERY-
dc.subject.keywordPlusRAT-LIVER-
dc.subject.keywordPlusRECEPTOR-
dc.subject.keywordPlusENDOCYTOSIS-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusCYTOTOXICITY-
dc.subject.keywordPlusSTRATEGIES-
dc.subject.keywordPlusTHERAPIES-
dc.subject.keywordPlusCOMPLEXES-
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